'Mature' nerve growth factor is a minor species in most peripheral tissues.
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Summary
It is demonstrated that 'mature' forms of NGF, i.e., the 13 and 16kDa species, are rare in sympathetic and sensory ganglia and in their peripheral targets, and that large molecular weight NGF precursors are abundant.
- Type
- article
- Published
- 2005-05-20
- Cited by
- 60
- References
- 23
- OpenAlex
- https://openalex.org/W2005174340
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31886730
Keywords
Nerve growth factor, Neurotrophin, Neurotrophin-3, Peripheral, Peripheral nervous system
References
- Structure and biosynthesis of nerve growth factor.
- Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF.
- Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease
- ProNGF: a neurotrophic or an apoptotic molecule?
- Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis
- Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
- Commercial Recombinant Human β‐Nerve Growth Factor and Adult Rat Dorsal Root Ganglia Contain an Identical Molecular Species of Nerve Growth Factor Prohormone
- Sortilin is essential for proNGF-induced neuronal cell death
- Reduced age‐related plasticity of neurotrophin receptor expression in selected sympathetic neurons of the rat
- Plasticity of aged perivascular axons following exogenous NGF: analysis of catecholamines.
- Nerve growth factor-like immunoreactivities in rodent salivary glands and testis
- Differential RNA splicing predicts two distinct nerve growth factor precursors
- Pro-sequence assisted folding and disulfide bond formation of human nerve growth factor.
- Evidence for reduced accumulation of exogenous neurotrophin by aged sympathetic neurons.
- Sympathetic neurons synthesize and secrete pro-nerve growth factor protein.
- The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
- Regulation of Cell Survival by Secreted Proneurotrophins
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
- Heterogeneous Requirement of NGF for Sympathetic Target Innervation In Vivo
- The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease.
Cited by
- Le facteur de croissance des nerfs NGF dans l'inflammation et le remodelage bronchique dans l'asthme
- The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
- The mature/pro nerve growth factor ratio is decreased in the brain of diabetic rats: Analysis by ELISA methods.
- Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF
- Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation*
- Neurotrophins and Nerve Regeneration-associated genes are expressed in the Cornea after Lamellar Flap Surgery
- The Proform of Glia Cell Line-Derived Neurotrophic Factor: a Potentially Biologically Active Protein
- Decreased adrenoceptor stimulation in heart failure rats reduces NGF expression by cardiac parasympathetic neurons
- Estrogen regulation of neurotrophin expression in sympathetic neurons and vascular targets.
- p75 and TrkA signaling regulate sympathetic neuronal firing patterns via differential modulation of voltage-gated currents
- Transsynaptic activity-dependent regulation of axon branching and neurotrophin expression in vivo
- Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy.
- Changes in NGF and NT-3 protein species in the superior cervical ganglion following axotomy of postganglionic axons
- Expression Profile of Nerve Growth Factor after Muscle Incision in the Rat
- Nerve Growth Factor Expression after Plantar Incision in the Rat
- Cardiovascular effects of the nerve growth factor: An analytical review. Part I: NGF-mediated intracellular signaling pathways
- Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties
- p75 neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis
- Distribution of nerve growth factor, pro-nerve growth factor, and their receptors in human salivary glands.
- Processing of nerve growth factor: the role of basic amino acid clusters in the pro-region.
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