The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
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Summary
It is demonstrated here that the latent reservoir of HIV-1 decays with a mean half-life of 6.3 months in patients who consistently maintain plasma HIV- 1 RNA levels of fewer than 50 copies/ml, and in individuals who experience intermittent episodes of plasma viremia.
- Type
- article
- Published
- 2000-01-01
- Cited by
- 495
- References
- 25
- OpenAlex
- https://openalex.org/W2004246558
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23159540
Keywords
Viremia, Viral replication, Virology, Peripheral blood mononuclear cell, Virus latency
References
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- Higher selection pressure from antiretroviral drugs in vivo results in increased evolutionary distance in HIV-1 pol.
Cited by
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- Structure modifications of 6-aminoquinolones with potent anti-HIV activity.
- Therapeutic response of HIV-1 subtype C in African patients coinfected with either Mycobacterium tuberculosis or human herpesvirus-8.
- Antiretroviral Therapy, Hepatitis C Virus, and AIDS Mortality Among San Francisco's Homeless and Marginally Housed
- Novel Phorbol Esters Exert Dichotomous Effects on Inhibition of HIV-1 Infection and Activation of Latent HIV-1 Expression
- Viral and Latent Reservoir Persistence in HIV-1–Infected Patients on Therapy
- Limits on Replenishment of the Resting CD4+ T Cell Reservoir for HIV in Patients on HAART
- Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells
- Human Immunodeficiency Virus (HIV) Latency: The Major Hurdle in HIV Eradication
- CD4 count and viral load specific rates of AIDS, non‐AIDS and deaths according to current antiretroviral use
- Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults.
- FUNCTIONALIZED POLYMERIC MEMBRANES FOR BIOSEPARATION AND BIOCATALYSIS
- Tactics used by HIV‐1 to evade host innate, adaptive, and intrinsic immunities
- Update on HIV-1 viral load blips
- Interactions du VIH-1 avec ses cellules cibles : recherche de nouveaux réservoirs et analyse du contrôle de la latence
- A Guide to HIV-1 Reverse Transcriptase and Protease Sequencing for Drug Resistance Studies.
- A Control Theoretic Approach to HIV/AIDS Drug Dosage Design and Timing the Initiation of Therapy
- Ludwik Hirszfeld Memorial Lecture: HIV-1 reservoirs: major molecular obstacles to viral eradication.
- HIV Reservoir Dynamics in the Face of Highly Active Antiretroviral Therapy
- Viral persistence, latent reservoir, and blips: a review on HIV-1 dynamics and modeling during HAART and related treatment implications
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