A Family of Bioreducible Poly(disulfide amine)s for Gene Delivery
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Summary
A family of bioreducible poly(disulfide amine)s, which differ in the length of polymethylene spacer in the main chain and the side chain, have been synthesized and are promising safe and efficient non-viral vectors for gene delivery.
- Type
- article
- Published
- 2009-07-16
- Cited by
- 107
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2003017093
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37604435
Keywords
Materials science, Disulfide bond, Amine gas treating, Organic chemistry, Biochemistry
References
- New AAV serotypes may broaden the therapeutic pipeline to human gene therapy.
- Gene therapy - promises, problems and prospects
- Glutathione metabolism and its implications for health.
- Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells
- A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs.
- Characterizing the structure/function parameter space of hydrocarbon-conjugated branched polyethylenimine for DNA delivery in vitro.
- Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine.
- Combinatorial evaluation of cations, pH-sensitive and hydrophobic moieties for polymeric vector design.
- Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery.
- Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes*
- Nonviral vectors for gene delivery.
- Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery.
- Design and development of polymers for gene delivery
- Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery.
- A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
- Overcoming limiting side reactions associated with an NHS-activated precursor of polymethacrylamide-based polymers.
- Polymers for gene delivery across length scales
- Structure-function relationships of gene delivery vectors in a limited polycation library.
- Nonviral gene therapy: promises and challenges
- Polycation gene delivery systems: escape from endosomes to cytosol
Cited by
- Block copolymer micelles with a dual-stimuli-responsive core for fast or slow degradation.
- Screening Nylon-3 Polymers, a New Class of Cationic Amphiphiles, for siRNA Delivery
- Synthetic polynucleotides as endosomolytic agents and bioenergy sources.
- Reducible chimeric polypeptide consisting of octa-d-arginine and tetra-l-histidine peptides as an efficient gene delivery vector
- Bioreducible polyspermine as less toxic and efficient gene carrier
- EphA2 targeting peptide tethered bioreducible poly(cystamine bisacrylamide - diamino hexane) for the delivery of therapeutic pCMV-RAE-1γ to pancreatic islets
- Bioreducible polymers as a determining factor for polyplex decomplexation rate and transfection
- Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery
- A comparative study of three ternary complexes prepared in different mixing orders of siRNA/redox-responsive hyperbranched poly (amido amine)/hyaluronic acid
- Bioreducible cross-linked polymers based on G1 peptide dendrimer as potential gene delivery vectors.
- Biodegradable poly(disulfide)s derived from RAFT polymerization: monomer scope, glutathione degradation, and tunable thermal responses.
- The Effect of Environmental pH on Polymeric Transfection Efficiency
- One-pot Synthesis of Functional Poly(amino ester sulfide)s and Utility in Delivering pDNA and siRNA
- Targeted siRNA therapy using cytoplasm-responsive nanocarriers and cell-penetrating peptides
- PAMAM dendrimer with a 1,2-diaminoethane surface facilitates endosomal escape for enhanced pDNA delivery
- Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy
- Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties
- pH and reduction dual-responsive nanogel cross-linked by quaternization reaction for enhanced cellular internalization and intracellular drug delivery
- PEGylated Peptide Based Reductive Polycations as Efficient Nonviral Gene Vectors
- C/EBP-α and C/EBP-β-mediated adipogenesis of human mesenchymal stem cells (hMSCs) using PLGA nanoparticles complexed with poly(ethyleneimmine).
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