Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family.
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Summary
These findings strongly implicate Spo11 as the catalytic subunit of the meiotic DNA cleavage activity and provide direct evidence that the mechanism of meiotic recombination initiation is evolutionarily conserved.
- Type
- article
- Published
- 1997-02-07
- Cited by
- 1,859
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W2002454928
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8294596
Keywords
Biology, Schizosaccharomyces pombe, Homologous recombination, Saccharomyces cerevisiae, Genetics
References
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- The yeast MER2 gene is required for chromosome synapsis and the initiation of meiotic recombination.
Cited by
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- DNA-dependent protein kinase: DNA binding and activation in the absence of Ku.
- Yeast Meiosis-Specific Protein Hop1 Binds to G4 DNA and Promotes Its Formation
- HO endonuclease-induced recombination in yeast meiosis resembles Spo11-induced events.
- Most meiotic CAG repeat tract-length alterations in yeast are SPO11 dependent
- Homologous recombination: ends as the means.
- Details and concerns regarding the G2/M DNA damage checkpoint in budding yeast.
- VDE‐initiated intein homing in Saccharomyces cerevisiae proceeds in a meiotic recombination‐like manner
- The genetics and molecular biology of the synaptonemal complex.
- Role of the N-terminal Domain of the Human DMC1 Protein in Octamer Formation and DNA Binding*
- Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.
- Tying SUMO modifications to dynamic behaviors of chromosomes during meiotic prophase of Saccharomyces cerevisiae.
- Fine structure mapping of a gene-rich region of wheat carrying Ph1, a suppressor of crossing over between homoeologous chromosomes
- Transcriptomic Analysis of Toxoplasma Development Reveals Many Novel Functions and Structures Specific to Sporozoites and Oocysts
- Deep Genome-Wide Measurement of Meiotic Gene Conversion Using Tetrad Analysis in Arabidopsis thaliana
- Targeted meiotic recombination in Arabidopsis thaliana
- Evolution of recombination in eutherian mammals: insights into mechanisms that affect recombination rates and crossover interference
- Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana
- Mismatch repair during homologous and homeologous recombination.
- XRCC3 is essential for proper double-strand break repair and homologous recombination in rice meiosis.
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