Early and late changes in sulphydryl group and copper protein concentrations and activities during drug treatment with aurothiomalate and auranofin.
Explore this paper's citation graph
Summary
The intracellular parameters appear to reflect an early effect of the drugs on cells which may possibly be of use in predicting the outcome of therapy, whereas the extracellular parameters provide confirmatory evidence for an eventual improvement.
- Type
- article
- Published
- 1986-10-01
- Cited by
- 15
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W2002154397
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10716524
Keywords
Auranofin, Medicine, Ceruloplasmin, Placebo, Superoxide dismutase
References
- Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.
- Ceruloplasmin. A scavenger of superoxide anion radicals.
- Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.
- A relationship between thiols and the superoxide ion
- Effects of antirheumatic drugs on protein sulphydryl reactivity of human serum
- Auranofin. New oral gold compound for treatment of rheumatoid arthritis.
- Tissue sulfhydryl groups.
- Serum copper and related variables in rheumatoid arthritis.
- Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis.
- Modification of a P-Phenylenediamine Oxidase Method to Permit Non-Automated Ceruloplasmin Determinations in Batches of Rat Serum or Plasma Microsamples
- Superoxide-dismutase deficiency in rheumatoid arthritis.
- On the effects of antirheumatic drugs on protein sulphydryl reactivity in human serum
- Superoxide dismutase: a photochemical augmentation assay.
- Serum copper and its relationship to clinical symptoms in rheumatoid arthritis.
- The assessment of disease activity in rheumatoid arthritis using a multivariate analysis.
- Leucocyte superoxide dismutase in rheumatoid arthritis.
- The chemistry of the gold drugs used in the treatment of rheumatoid arthritis
- TISSUE SULPHYDRYL GROUPS
- D-penicillamine-induced increase in intracellular glutathione correlating to clinical response in rheumatoid arthritis.
- Auranofin: an oral chrysotherapeutic agent for the treatment of rheumatoid arthritis.
Cited by
- Free Radical Activity in Type 2 Diabetes
- Copper complexes offer a physiological approach to treatment of chronic diseases.
- The pharmacology and biochemical action of second-line agents.
- Clinical analysis in intact erythrocytes using 1H spin echo NMR.
- Calcium channel blockers and antioxidant levels
- Free radical pathology in chronic arterial disease.
- Spin‐echo 1H NMR detected response of ergothioneine to oxidative stress in the intact human erythrocyte
- Thiols, gold-thiols, zinc-thiols and the redox state of hemoglobin.
- Action of sodium aurothiomalate on erythrocyte membrane.
- FREE RADICALS AND GRAVES' DISEASE: THE EFFECTS OF THERAPY
- Concentration and reactivity of the sulphydryl group population on the membrane of intact erythrocytes in patients with rheumatoid arthritis.
- Influences of gold on zinc, copper and metallothionein kinetics in liver and kidney of the rat
- The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis
- Gold(I)-thiolates: slow-acting anti-arthritic drugs
- Prediction of the clinical efficacy of and intolerance to antirheumatic drug therapy
Related papers
- Inhibition of production of macrophage-derived angiogenic activity by the anti-rheumatic agents gold sodium thiomalate and auranofin.
- The effect of longterm treatment with auranofin and gold sodium thiomalate on immune function in the dog.
- Synergistic inhibition of T cell proliferation by gold sodium thiomalate and auranofin.
- The effect of gold sodium thiomalate and auranofin on lipopolysaccharide‐induced interleukin‐1 production by blood monocytes in vitro: variation in healthy subjects and patients with arthritis
- Do gold drugs inhibit interleukin-1? Evidence from an in vitro lymphocyte activating factor assay.
- Induction of stress proteins in mouse peritoneal macrophages by the anti-rheumatic agents gold sodium thiomalate and auranofin.
- Distribution of gold in rat blood after intravenous administration of auranofin, gold sodium thiomalate and aurothioglucose to rats.
- The effects of auranofin and gold sodium aurothiomalate on the chemiluminescent response of stimulated synovial tissue cells from patients with rheumatoid arthritis.
- Biologic actions and pharmacokinetic studies of auranofin.
- Latent human leukocyte collagenase can be activated by gold thioglucose and gold sodium thiomalate, but not by auranofin