Intensity of malaria transmission and the evolution of drug resistance.
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Summary
It is argued that the evolution of resistance is likely to be a two-stage process: mutations encoding drug tolerance preceding those encoding resistance, with the most likely scenarios are that resistance evolves faster in areas of high transmission if encoded by a single gene but if encoding by two or more genes it evolves fastest in Areas of high or low transmission.
- Type
- review
- Published
- 2005-06-01
- Cited by
- 95
- References
- 36
- OpenAlex
- https://openalex.org/W2002055028
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5901157
Keywords
Transmission (telecommunications), Malaria, Drug resistance, Biology, Genetics
References
- Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand.
- Clinical features cannot predict a diagnosis of malaria or differentiate the infecting species in children living in an area of low transmission.
- A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by Chloroquine treatment in Tanzania.
- Modelling the development of resistance of Plasmodium falciparum to anti-malarial drugs.
- Intercontinental Spread of Pyrimethamine-Resistant Malaria
- Antifolate antimalarial resistance in southeast Africa: a population-based analysis.
- The evolution of drug-resistant malaria: the role of drug elimination half-life.
- Estimation of inbreeding coefficients from genotypic data on multiple alleles, and application to estimation of clonality in malaria parasites.
- The emergence of drug-resistant malaria
- Using evidence to change antimalarial drug policy in Kenya
- Malaria control and the evolution of drug resistance: an intriguing link.
- Intensity of malaria transmission, antimalarial-drug use and resistance in Uganda: what is the relationship between these three factors?
- A model for the origins and spread of drug-resistant malaria
- Survival probability of drug resistant mutants in malaria parasites
- Do malaria parasites mate non-randomly in the mosquito midgut?
- Mating patterns in malaria parasite populations of Papua New Guinea.
- Modelling a predictable disaster: the rise and spread of drug-resistantmalaria.
- Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?
- The de novo selection of drug–resistant malaria parasites
- Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life.
Cited by
- Artemisia, Agriculture and Malaria in Africa: The Interplay of Tradition, Science and Public Policy
- Probability of emergence of antimalarial resistance in different stages of the parasite life cycle
- Modelling malaria population structure and its implications for control.
- Dihydroartemisinin esters as prodrugs against resistant P. falciparum strains
- Spatial and temporal analyses of sulphadoxine pyrimethamine resistance in African Plasmodium falciparum malaria
- Modelling parasite transmission and control
- Experimental studies on the ecology and evolution of drug-resistant malaria parasites
- Artemisia annua, Artemisinin, ACTs and Malaria Control in Africa: The Interplay of Tradition, Science and Public Policy
- Drug Analysis : Bioanalytical Method Development and Validation
- Global Transport Networks and Infectious Disease Spread
- Drug resistant malaria in Papua New Guinea and molecular monitoring of parasite resistance
- BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION
- Treatment of uncomplicated malaria in Guinea-Bissau
- Complex dynamics and stability of resistance to antimalarial drugs
- Amodiaquine combined with sulfadoxine/pyrimethamine versus artemisinin-based combinations for the treatment of uncomplicated falciparum malaria in Africa: a meta-analysis.
- Ampelozyziphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites.
- The decline of northern malaria and population dynamics of Plasmodium vivax
- Drug resistant Plasmodium falciparum in an area of seasonal transmission.
- Tolerance is the key to understanding antimalarial drug resistance.
- Diversity of Plasmodium falciparum Chloroquine Resistance Transporter (pfcrt) Exon 2 Haplotypes in the Pacific from 1959 to 1979
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