Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
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Summary
These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
- Type
- review
- Published
- 2002-11-01
- Cited by
- 5,473
- References
- 73
- OpenAlex
- https://openalex.org/W2001717792
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34998883
Keywords
Immunology, Macrophage, Macrophage polarization, Phenotype, Biology
References
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- The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.
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- The Effect of 17β-Estradiol on Cutaneous Wound Healing in Protein-Malnourished Ovariectomized Female Mouse Model
- Expression of chemokines and chemokine receptors in human colon cancer.
- Immunohistochemical study of colorectal cancer liver metastases: the immune/inflammatory infiltrate.
- Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases.
- Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea.
- Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
- Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
- Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma.
- Rhinovirus Replication in Human Macrophages Induces NF-κB-Dependent Tumor Necrosis Factor Alpha Production
- Myelin‐phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
- The role of the tumor microenvironment in metastasis studied by intravital imaging
- Suppressive Influences in the Immune Response to Cancer
- Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
- Stemming vision loss with stem cells.
- Alternative activation of tumor-associated macrophages by IL-4
- Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice.
- Influence of CD8+ T regulatory cells on intraocular tumor development
- Characterization of Human Adipose Tissue-Resident Hematopoietic Cell Populations Reveals a Novel Macrophage Subpopulation with CD34 Expression and Mesenchymal Multipotency
- Progressive growth of a murine T cell lymphoma alters population kinetics and cell viability of macrophages in a tumor-bearing host
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