Current methods in structural proteomics and its applications in biological sciences
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Summary
The current status of SP methods for the structure determination pipeline, including target selection, isolation, expression, purification, crystallization, diffraction data collection, structure solution, refinement and functional annotation are reviewed.
- Type
- article
- Published
- 2011-12-10
- Cited by
- 26
- References
- 236
- Access
- Open access
- OpenAlex
- https://openalex.org/W2001656498
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1257154
Keywords
Proteomics, Pipeline (software), Computational biology, Structural genomics, Computer science
References
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- The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery.
- Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center
- The Buccaneer software for automated model building
- The protein structure initiative structural genomics knowledgebase
- The relation between the divergence of sequence and structure in proteins.
- ARP/wARP and automatic interpretation of protein electron density maps.
- Project management system for structural and functional proteomics: Sesame
- Processing of X-ray diffraction data collected in oscillation mode.
- Establishing the yeast Saccharomyces cerevisiae as a system for expression of human proteins on a proteome-scale
- Getting a Grip
- Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis
- Crystal structure of the human β2 adrenergic G-protein-coupled receptor
- New surface contacts formed upon reductive lysine methylation: Improving the probability of protein crystallization
- Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii
Cited by
- Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome
- Growth of Diffraction-Quality Protein Crystals Using a Harvestable Microfluidic Device
- Biotechnological Advances in Methods for Functional Analysis of Genes
- Structural and Functional Characterization of Iron-Containing Oxygenases from Pseudomonas aeruginosa
- Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics
- Systems biophysics: Single-molecule optical proteomics in single living cells
- Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
- Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury
- Using sound pulses to solve the crystal-harvesting bottleneck
- Comparison of Peptide Ion Conformers Arising from Non-Helical and Helical Peptides Using Ion Mobility Spectrometry and Gas-Phase Hydrogen/Deuterium Exchange
- Proteome study of somatic embryogenesis in Nothapodytes nimmoniana (J. Graham) Mabberly
- Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives
- Towards an Optimal Sample Delivery Method for Serial Crystallography at XFEL
- pmTM-align: scalable pairwise and multiple structure alignment with Apache Spark and OpenMP
- Proteomics for the study of new biomarkers in Fabry disease: State of the art.
- Computational-approach understanding the structure-function prophecy of Fibrinolytic Protease RFEA1 from Bacillus cereus RSA1
- Recent developments in systems biology and genetic engineering toward design of vaccines for TB
- Integrin-linked kinase (ILK): the known vs. the unknown and perspectives
- Virus-host protein-protein interactions as molecular drug targets for arboviral infections
- Algorithmically-guided discovery of viral epitopes via linguistic parsing: Problem formulation and solving by soft computing
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