Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8
Explore this paper's citation graph
Summary
Recent genome-wide studies identified Zfp804a (or ZNF804A in humans) as a plausible marker for schizophrenia, leading us to hypothesize that this embryogenic regulatory control might also exert influence in development of complex traits such as psychosis.
- Type
- article
- Published
- 2010-05-25
- Cited by
- 28
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2001237260
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15312925
Keywords
Biology, Gene, Downregulation and upregulation, Psychosis, Embryo
References
- Analysis of plausible downstream target genes of Hoxc8 in F9 teratocarcinoma cells – Putative downstream target genes of Hoxc8
- Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells
- SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation.
- A Homeotic Gene, Hoxc8, Regulates the Expression of Proliferating Cell Nuclear Antigen in NIH3T3 Cell
- Hox genes in neural patterning and circuit formation in the mouse hindbrain.
- Evolution of the vertebrate Hox homeobox genes
- "Mir"acles in hox gene regulation.
- Smad1 Domains Interacting with Hoxc-8 Induce Osteoblast Differentiation*
- The Zinc Finger Protein 202 (ZNF202) Is a Transcriptional Repressor of ATP Binding Cassette Transporter A1 (ABCA1) and ABCG1 Gene Expression and a Modulator of Cellular Lipid Efflux*
- Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain.
- Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation *
- The identification of Hoxc8 target genes.
- Neural Mechanisms of a Genome-Wide Supported Psychosis Variant
- Homeobox genes and axial patterning.
- Smads oppose Hox transcriptional activities.
- Cross-regulation of Hox genes in the Drosophila melanogaster embryo.
- Identification of loci associated with schizophrenia by genome-wide association and follow-up
- Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2--Hox-3.1 intergenic region.
- Hox genes in vertebrate development.
- HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes.
Cited by
- ZNF804A may be associated with executive control of attention
- Expression and neural correlates of schizophrenia risk gene ZNF804A
- A Review of Common and Rare Genetic Variants in Schizophrenia
- Effects of ENU mutations of Zfp804a on behavioural phenotypes
- Palatability and animal models of schizophrenia
- Connectomic Intermediate Phenotypes for Psychiatric Disorders
- No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: A tract-based spatial statistics study
- ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype
- Lack of association of the rs1344706 ZNF804A variant with cognitive functions and DTI indices of white matter microstructure in two independent healthy populations.
- ZNF804A rs1344706 Variant and Schizophrenia in a Romanian Population from Cluj Napoca
- Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706.
- Novel schizophrenia risk genesand gene expression
- Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.
- Genome‐wide supported psychosis risk variant in ZNF804A gene and impact on cortico–limbic WM integrity in schizophrenia
- Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries
- ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls
- Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion
- The psychosis susceptibility gene ZNF804A: associations, functions, and phenotypes.
- ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies.
- Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis.
Related papers
- Enzyme-Instructed Assembly and Disassembly Processes for Targeting Downregulation in Cancer Cells
- Downregulation of p21/WAF1 expression by thymidylate synthase.
- Viral Infection and Abnormal Brain Development: A DNA Microarray Study
- Downregulation of POLD4 in Calu6 cells results in G1-S blockage through suppression of the Akt-Skp2-p27 pathway.
- Upregulation of β3-adrenoceptors—a general marker of and protective mechanism against hypoxia?
- Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
- Relative contribution of molecular mechanisms to cumulative ligand-mediated downregulation of GRα.
- Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
- The functional role of bestrophins and TMEM16A in rat mesenteric small arteries
- WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP