Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Explore this paper's citation graph
Summary
The data provide the first direct evidence for the source of proliferating cardiomyocytes during zebrafish heart regeneration and indicate that stem or progenitor cells are not significantly involved in this process.
- Type
- article
- Published
- 2010-03-25
- Cited by
- 1,353
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W1998457769
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4381408
Keywords
Zebrafish, Regeneration (biology), Cell biology, Biology, Myocyte
References
- Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts.
- Activation of Notch signaling pathway precedes heart regeneration in zebrafish
- Practical methods in electron microscopy
- Ultrastructural Pathology: An Introduction to Interpretation
- Gene Expression Analysis of Zebrafish Heart Regeneration
- A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.
- Transcriptomics approach to investigate zebrafish heart regeneration
- Germ‐line transmission of a myocardium‐specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish
- Can the cardiomyocyte cell cycle be reprogrammed?
- Response of the adult newt ventricle to injury.
- Electron microscopy characterization of cardiomyocyte apoptosis in ischemic heart disease.
- Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.
- Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
- Cell cycle reentry of ventricular and atrial cardiomyocytes and cells within the epicardium following amputation of the ventricular apex in the axolotl, Amblystoma mexicanum: confocal microscopic immunofluorescent image analysis of bromodeoxyuridine-labeled nuclei
- Re-programming of newt cardiomyocytes is induced by tissue regeneration
- FlEx-based transgenic reporter lines for visualization of Cre and Flp activity in live zebrafish
- Controlled expression of transgenes introduced by in vivo electroporation
- Temporally-Controlled Site-Specific Recombination in Zebrafish
- Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.
- Heart Regeneration in Zebrafish
Cited by
- Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways
- Generating Conditional Mutations in Zebrafish Using Gene-trap Mutagenesis
- [Progress in Cre/lox site-specific recombination system in higher eukaryotes].
- Cardiac Regeneration from Activated Epicardium
- Patching the Heart: Cardiac Repair from Within and Outside
- A Study of the Adult Zebrafish Ventricular Function by Retrospective Doppler-Gated Ultrahigh-Frame-Rate Echocardiography
- Harnessing the power of dividing cardiomyocytes
- Myocyte Dedifferentiation Drives Extraocular Muscle Regeneration in Adult Zebrafish.
- Possible Muscle Repair in the Human Cardiovascular System
- Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration
- Stem cell-based retina models.
- Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing
- Cell lineages, growth and repair of the mouse heart.
- Life before Nkx2.5: cardiovascular progenitor cells: embryonic origins and development.
- Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
- The regenerative activity of interleukin-6.
- Using Zinc Finger Nucleases for Targeted Genome Modification in the Zebrafish
- Estudi de la regeneració miocàrdica en la miocardiopatia alcohòlica i la seva relació amb el dany funcional i estructural miocàrdic, activació d’apoptosi i activitat miostatina
- Vertebrates that regenerate as models for guiding stem cels.
- Assembly and Disassembly of Myofibrils in Dissociated Cardiomyocytes
Related papers
- Tales of regeneration in zebrafish
- Heart Regeneration in Zebrafish
- Hooked on heart regeneration: the zebrafish guide to recovery
- Uncovering the Molecular and Cellular Mechanisms of Heart Development Using the Zebrafish
- Zebrafish in the Study of Early Cardiac Development
- Zebrafish models in cardiac development and congenital heart birth defects
- Biomechanics of cardiac development in zebrafish model
- Zebrafish hearts and minds: nodal signaling in cardiac and neural left-right asymmetry.
- Modeling Syndromic Congenital Heart Defects in Zebrafish.