Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheo-chromocytoma cells.
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Summary
Findings indicate that PC12 cells can release catecholamines by means of an exocytotic secretion mechanism, store most of their endogenous catechlamines in chromaffin granules and/or vesicles and have an uptake1-type transport system for norepinephrine.
- Type
- article
- Published
- 1977-07-01
- Cited by
- 397
- References
- 40
- OpenAlex
- https://openalex.org/W1998385128
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42601300
Keywords
Nerve growth factor, Veratridine, Catecholamine, Chromaffin cell, Reserpine
References
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Cited by
- Regulation of tyrosine hydroxylase and choline acetyltransferase activities by cell density in the PC12 rat pheochromocytoma clonal cell line.
- Properties of the nerve growth factor receptor of a clonal line of rat pheochromocytoma (PC12) cells.
- The reverse transforming effects of nerve growth factor on five human neurogenic tumor cell lines: in vitro results
- Stimulative effect of glia maturation factor and acetylcholine on active amino acid uptake and Ca2+,Mg2+-ATPase activity in nodose ganglia excised from adult rats.
- Permissive action of glucocorticoids in induction of tyrosine hydroxylase by nerve growth factor in a pheochromocytoma cell line.
- Large-scale preparation of plasma membrane vesicles from PC-12 pheochromocytoma cells and their use in noradrenaline transport studies.
- Modulation of a neuronal calmodulin mRNA species in the rat brain stem by reserpine
- Increased expression of monoamine oxidase‐B results in enhanced neurite degeneration in methamphetamine‐treated PC12 cells
- Comparative studies of PC12 and mouse pheochromocytoma-derived rodent cell lines as models for the study of neuroendocrine systems
- Catalponol enhances dopamine biosynthesis and protects against l-DOPA-induced cytotoxicity in PC12 cells
- Neuroprotective Effects of Bioactive Compounds and MAPK Pathway Modulation in “Ischemia”—Stressed PC12 Pheochromocytoma Cells
- THE ROLE OF DOPAMINE OXIDATION IN DOPAMINE-INDUCED TOXICITY, INITIATION OF ENDOPLASMIC RETICULUM STRESS, AND POTENTIATION OF ROTENONE-INDUCED TOXICITY IN DIFFERENTIATED PC12 CELLS
- Evaluation of a hyperbaric system to be used in conjunction with a fluorometer.
- The Role of Globo-Series Glycolipids in Neuronal Cell Differentiation—A Review
- PC12 cells as a window for the differentiation of neural crest into adrenergic nerve ending and adrenal medulla.
- Ca2+-dependent phosphorylation by endogenous kinases of Mr 95 K and 50 K-55 K proteins in PC12 pheochromocytoma cells
- First continuous human pheochromocytoma cell line: KNA Biological, cytogenetic and molecular characterization of KNA cells
- The Mechanisms of Exocytosis Studied in Cells and Models with Amperometry
- Amine Oxidases and Their Impact on Neurobiology
- Polymer encapsulated dopaminergic cell lines as "alternative neural grafts".
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