Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene.
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Summary
Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.
- Type
- article
- Published
- 2011-06-08
- Cited by
- 428
- References
- 26
- OpenAlex
- https://openalex.org/W1997990070
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205794521
Keywords
Graphene, Surface modification, Toxicity, Oxidative stress, Membrane
References
- A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics
- Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs.
- Carbon-nanotube shape and individualization critical for renal excretion.
- Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy.
- PEGylated Nano-Graphene Oxide for Delivery of Water Insoluble Cancer Drugs
- DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells.
- CELL-PENETRATING CNTS FOR DELIVERY OF THERAPEUTICS
- In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes.
- Electric Field Effect in Atomically Thin Carbon Films
- High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide
- Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants.
- Interfacing carbon nanotubes with living mammalian cells and cytotoxicity issues.
- Graphene: the new two-dimensional nanomaterial.
- Graphene: Status and Prospects
- Physicochemical properties affecting cellular uptake of carbon nanotubes.
- Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes.
- Two-dimensional gas of massless Dirac fermions in graphene
- Functionalized single graphene sheets derived from splitting graphite oxide.
- Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type.
- The problem of purifying single-walled carbon nanotubes.
Cited by
- Graphene and its derivatives for cell biotechnology.
- Biocompatibility of pristine graphene for neuronal interface.
- Toxic response of graphene nanoplatelets in vivo and in vitro
- An assessment of the cytotoxic effects of graphene nanoparticles on the epithelial cells of the human lung
- Applications of Nanosheets in Frontier Cellular Research
- Is Graphene a Promising Nano-Material for Promoting Surface Modification of Implants or Scaffold Materials in Bone Tissue Engineering?
- In vitro toxicity evaluation of graphene oxide on human RPMI 8226 cells
- Synthesis and physicochemical characteristics of the calcium hydroxyapatite/graphene oxide hybrid nanocomposite
- Covalently Coupled Ultrafine H-TiO2 Nanocrystals/Nitrogen-Doped Graphene Hybrid Materials for High-Performance Supercapacitor.
- Biomedical applications of gold nanomaterials: opportunities and challenges.
- Toxicity of graphene nanoflakes evaluated by cell-based electrochemical impedance biosensing.
- Applications and nanotoxicity of carbon nanotubes and graphene in biomedicine
- Graphene: A Versatile Carbon-Based Material for Bone Tissue Engineering
- Cell response of nanographene platelets to human osteoblast-like MG63 cells.
- Screening of toxic potential of graphene family nanomaterials using in vitro and alternative in vivo toxicity testing systems
- The interfacial-organized monolayer water film (MWF) induced "two-step" aggregation of nanographene: both in stacking and sliding assembly pathways.
- Nanomaterials for Engineering Stem Cell Responses
- In vitro toxicity of carbon nanotubes, nano-graphite and carbon black, similar impacts of acid functionalization.
- Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film
- Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy
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