The control of cell motility and epithelial morphogenesis by Jun kinases.
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Summary
Recent advances in understanding the role of JNK pathway in the regulation of cell migration, cytoskeleton rearrangement and the morphogenesis of epithelial sheets are focused on.
- Type
- review
- Published
- 2004-02-01
- Cited by
- 266
- References
- 78
- OpenAlex
- https://openalex.org/W1997663906
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26167410
Keywords
Biology, Cell biology, Morphogenesis, Kinase, Cell migration
References
- Strain-dependent epithelial defects in mice lacking the EGF receptor.
- A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase.
- The Ste20 Kinase Misshapen Regulates Both Photoreceptor Axon Targeting and Dorsal Closure, Acting Downstream of Distinct Signals
- Planar polarity and actin dynamics in the epidermis of Drosophila
- Disruption of Basal JNK Activity Differentially Affects Key Fibroblast Functions Important for Wound Healing*
- The TAO of MEKK.
- Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
- Eyelid development, fusion and subsequent reopening in the mouse.
- The true face of JNK activation in apoptosis
- Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.
- Rapid and preferential activation of the c-jun gene during the mammalian UV response
- An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.
- c-Jun is essential for organization of the epidermal leading edge.
- Epithelial morphogenesis: filopodia at work.
- Molecular Cloning and Characterization of a Novel Protein Kinase with a Catalytic Domain Homologous to Mitogen-activated Protein Kinase Kinase Kinase*
- Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
- Dynamic analysis of actin cable function during Drosophila dorsal closure.
- Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement.
- The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
- MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.
Cited by
- Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.
- The biphasic nature of hypoxia‐induced directional migration of activated human hepatic stellate cells
- Analysis of Wnt7a-stimulated JNK activity and cJun phosphorylation in non-small cell lung cancer cells.
- How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from Drosophila.
- The interplay of JNK and SCG10 during cortical development and in excitotoxic responses in brain
- Identification and functional analysis of Hox downstream genes in Drosophila
- Bidirectional communication between tissues regulating morphogenesis in a Drosophila model of wound healing
- The role of brain endothelial MAP kinases in ICAM-1-mediated lymphocyte transmigration
- Grainy head target genes in epithelial morphogenesis and wound healing
- The role of PKN in cell movement
- Implication de l'endosome de recyclage dans la migration cellulaire in vivo
- Role of the cJun NH2-Terminal Kinase (JNK) in Cancer: A Dissertation
- MEK kinase 1: kinase domain deficiency in mice reveals a role in orchestrating the thymus-dependent immunity and TNFR family signaling.
- A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma
- Investigating Pathogenic Mechanisms of the Helicobacter pylori Virulence Factor CagA Using Transgenic Expression in Drosophila melanogaster
- JNK regulation of oncogenesis.
- M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
- The Role of Pax6 in Lens Placode Formation
- Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis.
- Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells.
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