Thymidine Transport in the Central Nervous System
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Summary
Results were interpreted as showing that the entry of thymidine from blood into CSF and presumably the extracellular space of brain and then into brain cells involves one or more saturable transport and/or metabolic steps.
- Type
- article
- Published
- 1980-11-01
- Cited by
- 41
- References
- 19
- OpenAlex
- https://openalex.org/W1997160691
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19895540
Keywords
Thymidine, Choroid plexus, Efflux, Thymidine kinase, Internal medicine
References
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- Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat.
- Pharmacokinetic studies during phase I trials of high-dose thymidine infusions.
- Thymidine concentrations in serum and urine of different animal species and man.
- Incorporation of pyrimidine deoxyribonucleosides into liver lipids and other components.
- Inositol accumulation by brain slices in vitro
- NUCLEOTIDE METABOLISM IN RAT BRAIN
- Independent blood-brain barrier transport systems for nucleic acid precursors.
- Thymidine accumulation by choroid plexus in vitro.
- Separation of deoxythymidine and deoxythymidine nucleotides by column and thin-layer chromatography.
- VITAMIN B6 TRANSPORT IN THE CENTRAL NERVOUS SYSTEM: IN VIVO STUDIES
- The relationship of thymidine metabolism to the use of fractional incorporation as a measure of DNA synthesis and tissue proliferation.
- Developmental changes in the subcellular distribution of thymidine kinase in the rat cerebellum.
- Problems in the use of (Me- 3H) thymidine for the measurement of DNA synthesis.
- Morphine induced increases in the incorporation of 3H-thymidine into brain striatal DNA.
- VITAMIN B6 TRANSPORT IN THE CENTRAL NERVOUS SYSTEM: IN VITRO STUDIES
- SECRETION OF CEREBROSPINAL FLUID BY CHOROID PLEXUS OF THE RABBIT.
- Thymidine and thymine in biologic fluids during high-dose infusions of thymidine in mice, monkeys, and man.
- [106] Methods for characterization of nucleic acids by base composition
Cited by
- Formycin B Elimination from the Cerebrospinal Fluid of the Rat
- In Vitro and in Vivo Transport of Zidovudine (AZT) Across the Blood–Brain Barrier and the Effect of Transport Inhibitors
- Short-term thymidine uptake in normal and neoplastic tissues: studies for PET.
- Imaging of brain tumor proliferative activity with iodine-131-iododeoxyuridine.
- Transport of alovudine (3'-fluorothymidine) into the brain and the cerebrospinal fluid of the rat, studied by microdialysis.
- Metabolism of Deoxyuridine in Rabbit Brain
- Hydrogen peroxide-induced thymidine incorporation into cultured rat astrocytes.
- Deoxycytidine Transport and Metabolism in Choroid Plexus
- Micronutrient and Urate Transport in Choroid Plexus and Kidney: Implications for Drug Therapy
- Quantification of efflux into the blood and brain of intraventricularly perfused [3H]thymidine in the anaesthetized rabbit
- Nucleoside and Vitamin Homeostasis in the Mammalian Central Nervous System
- Determination of ribonucleosides, deoxyribonucleosides, and purine and pyrimidine bases in adult rabbit cerebrospinal fluid and plasma
- Tritiated thymidine experiments in the cat: a description of techniques and experiments to define the time-course of radioactive thymidine availability.
- Mechanisms of transport of nucleosides and nucleoside analogues in choroid plexus.
- Biotin transport and metabolism in the central nervous system
- Uridine Transport and Metabolism in the Central Nervous System
- The Origin of Deoxynucleosides in Brain: Implications for the Study of Neurogenesis and Stem Cell Therapy
- Specificity and Sodium Dependence of the Active Nucleoside Transport System in Choroid Plexus
- Characterization, Development, and Localization of the Deoxycytidine Phosphorylating Systems in Mammalian Brain
- Nucleoside and Oxypurine Homeostasis in Adult Rabbit Cerebrospinal Fluid and Plasma
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