Massively parallel exon capture and library-free resequencing across 16 individuals
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Summary
Modifications enabling simultaneous amplification and accurate shotgun sequencing of 50,000 exons are described, proving the scalability and accuracy of direct sequencing of MIP amplicons, which circumvents all shotgun library construction.
- Type
- letter
- Published
- 2009-04-06
- Cited by
- 203
- References
- 6
- Access
- Open access
- OpenAlex
- https://openalex.org/W1996547052
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2056101
Keywords
Massively parallel, Massive parallel sequencing, Computational biology, Genome, Computer science
References
- Direct selection of human genomic loci by microarray hybridization
- Accurate Whole Human Genome Sequencing using Reversible Terminator Chemistry
- Next-generation DNA sequencing
- Multiplex amplification of large sets of human exons
- Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay.
- knowledge-based potentials and structural filters Coarse-grained modeling of large RNA molecules with Material Supplemental
Cited by
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- Genomic approaches for the discovery of genes mutated in inherited retinal degeneration.
- Method development and application of Next Generation Sequencing in forward genetics
- Development of a next-generation sequencing method for BRCA mutation screening: a comparison between a high-throughput and a benchtop platform.
- Massively parallel analysis of cells and nucleic acids
- Barcode sequencing for understanding drug-gene interactions.
- Large-Scale Generation of Synthetic DNA Libraries: Sequence-Specific Priming of Reverse Transcription.
- Next-generation sequencing for cancer diagnostics: a practical perspective.
- High-throughput genomic analysis of virulence and resistance mechanisms among microbial pathogens
- Identification of causal sequence variants of disease in the next generation sequencing era.
- Regulation of flowering time by DELLA proteins in Arabidopsis thaliana
- Next-generation sequencing algorithms: from read mapping to variant detection
- Understanding and improving high-throughput sequencing data production and analysis
- Synteny-based mapping-by-sequencing enabled by targeted enrichment.
- MOLECULAR ALTERATIONS IN HUMAN GENETIC DISEASES THROUGH NEXT GENERATION SEQUENCING TECHNOLOGIES
- SAP—A Sequence Mapping and Analyzing Program for Long Sequence Reads Alignment and Accurate Variants Discovery
- Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
- Advances in understanding cancer genomes through second-generation sequencing
- The expanding scope of DNA sequencing
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