Homozygosity of chromosome 13 in retinoblastoma.
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Summary
The data indicate that approximately half of all retinoblastomas are homozygous for large portions of 13q, that the homozygosity occurs in vivo and not as an event secondary to culture of the tumor cells, and that chromosome 13 hom allele is not correlated with the degree of histopathologic differentiation of the tumors.
- Type
- article
- Published
- 1984-03-01
- Cited by
- 290
- References
- 11
- OpenAlex
- https://openalex.org/W1996465274
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45397604
Keywords
Retinoblastoma, Carcinogenesis, Chromosome, Genetics, Chromosome 13
References
- Patient with 13 chromosome deletion: evidence that the retinoblastoma gene is a recessive cancer gene.
- Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D.
- Mechanism of origin of complete hydatidiform moles
- Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
- Esterase D: a new human polymorphism
- Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14.
- Abnormalities of chromosome #13 in retinoblastomas from individuals with normal constitutional karyotypes.
- Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.
- Molecular heterogeneity of inherited antithrombin III deficiency.
- Retinoblastoma: a prototypic hereditary neoplasm.
- Isolation of a transforming sequence from a human bladder carcinoma cell line.
Cited by
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- Elevated expression of basic fibroblast growth factor messenger ribonucleic acid in acoustic neuromas.
- Accuracy of detection of the retinoblastoma gene by esterase D linkage.
- Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
- Molecular biological aspects of soft tissue tumors.
- Heterogeneity of genetic alterations in primary human breast tumors.
- Molecular etiology of low-penetrance retinoblastoma in two pedigrees.
- Identification of mutations in the Ki-ras gene in human retinoblastoma.
- Genetic aspects of cancer.
- Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.
- Retinoblastoma associated with congenital hypotonia: A case report and review of the literature
- Identification and functional analysis of a novel renal cell carcinoma (RCC) susceptibility gene from an RCC associated constitutional chromosomal translocation.
- Genetic control of susceptibility to diethylnitrosamine and dimethylbenzanthracene carcinogenesis in rats.
- Genetics, chance, and morphogenesis.
- 神経芽腫と網膜芽腫を合併した 1 男児例
- Functional Analysis of Cell Cycle Regulators Lkb1 and Mat1 in Genetically Engineered Mice
- Connecting Genotypes to Drug Sensitivities in HER2 Positive Cancer Cell Lines
- Genetic control of susceptibility to diethylnitrosamine carcinogenesis in inbred ACP (grc+) and R16 (grc) rats.
- Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.
- Genetics of cancer predisposition.
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