Recent progress in the biology and physiology of sirtuins
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Summary
The recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long the authors live are reviewed.
- Type
- review
- Published
- 2009-07-30
- Cited by
- 1,519
- References
- 85
- Access
- Open access
- OpenAlex
- https://openalex.org/W1996395636
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205217532
Keywords
Sirtuin, Biology, NAD+ kinase, SIRT2, Genome instability
References
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- A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci.
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- SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
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- The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
- Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
- SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
- SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study
- Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.
- Sirtuins in mammals: insights into their biological function.
- Sir2-Independent Life Span Extension by Calorie Restriction in Yeast
- miR-34a repression of SIRT1 regulates apoptosis
- SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
- Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.
- A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
- Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
- SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Cited by
- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance.
- Role of Sirtuin 1 in metabolic regulation.
- The heat dissipation limit theory and evolution of life histories in endotherms--time to dispose of the disposable soma theory?
- Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm
- Ginkgolide B Reduces LOX-1 Expression by Inhibiting Akt Phosphorylation and Increasing Sirt1 Expression in Oxidized LDL-Stimulated Human Umbilical Vein Endothelial Cells
- SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts
- A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory
- Sirtuin 6 Modulates Hypoxia-induced Apoptosis in Osteoblasts via Inhibition of Glycolysis: Implication for Pathogenesis of Periapical Lesions.
- The role of DNA damage and repair in atherosclerosis: A review.
- ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
- Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model
- Competitive regulation by transcription factors and DNA methylation in the bovine SIRT5 promoter: Roles of E2F4 and KLF6.
- Effect of resveratrol on expression of genes involved thermogenesis in mice and humans.
- Using the Experimental Evolution of Long-Lived Yeast Species for Testing Evolutionary Theories of Aging
- THE INTERSECTION BETWEEN DNA DAMAGE RESPONSE AND CELL DEATH PATHWAYS
- Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
- Effets des polyphénols de vin rouge sur la prolifération cellulaire et sur le métabolisme du resvératrol
- SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth.
- Implication des lymphocytes B et de BAFF dans l'apoptose des cellules épithéliales des glandes salivaires au cours du syndrome de Gougerot-Sjögren
- Genes that link the insulin/IGF-like signaling pathway to stress response
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