The “A, B and C” of Her-2 DNA vaccine development
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Summary
Significant anti-Her-2 and anti-tumor activity was observed when Her-2 transgenic mice were electro-vaccinated after Treg depletion, and it may be possible to amplify tumor immunity with improved strategies that can by-pass undue autoimmunity.
- Type
- review
- Published
- 2008-02-14
- Cited by
- 12
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1996259893
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11560654
Keywords
DNA vaccination, Virology, Computational biology, DNA, Medicine
References
- HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA- DRB1*0301 (DR3) gene
- A single autophosphorylation site confers oncogenicity to the Neu/ErbB‐2 receptor and enables coupling to the MAP kinase pathway.
- From Breast Cancer Immunobiology to Her-2 DNA Vaccine and Autoimmune Sequelae
- Pilot Study of an HLA-A2 Peptide Vaccine Using Flt3 Ligand as a Systemic Vaccine Adjuvant
- Cellular immunity to the Her-2/neu protooncogene.
- Broadening of Epitope Recognition During Immune Rejection of ErbB-2-Positive Tumor Prevents Growth of ErbB-2-Negative Tumor 1
- H2A- and H2E-Derived CD4+CD25+ Regulatory T Cells: A Potential Role in Reciprocal Inhibition by Class II Genes in Autoimmune Thyroiditis1
- HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice.
- Vaccination with Cytoplasmic ErbB-2 DNA Protects Mice from Mammary Tumor Growth Without Anti-ErbB-2 Antibody1
- Thyroglobulin-induced T-cell in vitro proliferation in Hashimoto's thyroiditis: identification of the responsive subset and effect of monoclonal antibodies directed to Ia antigens.
- Protection against mammary tumor growth by vaccination with full‐length, modified human ErbB‐2 DNA
- Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire.
- Analysis of HLA genes in families with autoimmune diabetes and thyroiditis.
- Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis.
- Autoimmune Murine Thyroiditis Relation to Histocompatibility (H-2) Type
- Xenogeneic immunization in mice using HER2 DNA delivered by an adenoviral vector
- Quantitative measurement of anti-ErbB-2 antibody by flow cytometry and ELISA.
- Activity of DNA vaccines encoding self or heterologous Her-2/neu in Her-2 or neu transgenic mice.
- The genetics of autoimmune thyroid disease.
- Tumor Regression and Autoimmunity in Patients Treated With Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Interleukin 2: A Phase I/II Study
Cited by
- Preclinical development of cancer vaccines
- Modulation Of Anti-Tumor Immune Response By Tgf-Β-Inducible Early Gene 1 (tieg1)
- Evolution of animal models in cancer vaccine development
- Her-2 DNA versus cell vaccine: immunogenicity and anti-tumor activity
- Genetic regulation of the response to Her-2 DNA vaccination in human Her-2 transgenic mice
- Human responses against HER-2-positive cancer cells in human immune system-engrafted mice
- A Multi-DNA Preventive Vaccine for p53/Neu-Driven Cancer Syndrome
- DNA vaccination against oncoantigens
- Vaccination with a plasmid DNA encoding HER-2/neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial
- In silico modeling and in vivo efficacy of cancer-preventive vaccinations.
- Cancer esearch rated Systems and Technologies : Mathematical Oncology ilico Modeling and In vivo Efficacy of R cer-Preventive Vaccinations
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