Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information.
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Summary
A comprehensive analytical strategy for the elucidation of the molecular structure of metabolite biomarkers detected in a metabonomics study, exemplified analyzing spot urine of a cohort of healthy, insulin sensitive subjects and clinically well characterized prediabetic, insulin resistant individuals is presented.
- Type
- article
- Published
- 2008-01-15
- Cited by
- 178
- References
- 0
- OpenAlex
- https://openalex.org/W1996216366
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5243157
Keywords
Chemistry, Identification (biology), Chromatography, Computational biology
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