Ubiquitylation of MEKK1 Inhibits Its Phosphorylation of MKK1 and MKK4 and Activation of the ERK1/2 and JNK Pathways*

Keywords

Ubiquitin ligase, MAP kinase kinase kinase, Cell biology, Chemistry, Phosphorylation

References

• Efficient inhibition of Escherichia coli RNA polymerase by the bacteriophage T4 AsiA protein requires that AsiA binds first to free sigma70.Theodore J Jardine — 2000
• TAK1 is a ubiquitin-dependent kinase of MKK and IKKChen Wang, Li Deng, Mei Hong — 2001
• Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.Toshiaki Yujiri — 1998
• MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.Ying Xia, Constantin Makris, Bing Su — 2000
• MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation.Toshiaki Yujiri, Margaret F. Ware, Christian Widmann — 2000
• Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.Gil Levkowitz, Hadassa Waterman, Seth A. Ettenberg — 1999
• Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins*Masahiro Yokouchi, Takeshi Kondo, Archana Sanjay — 2001
• GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinasesLynn E. Heasley, Brooke Storey, Gary R. Fanger — 1996
• Caspase-dependent Cleavage of Signaling Proteins during ApoptosisChristian Widmann, Spencer B. Gibson, Gary L. Johnson — 1998
• The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.Zhimin Lu, Shuichan Xu, Claudio A.P. Joazeiro — 2002
• Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7*Masahiro Yokouchi, Takeshi Kondo, Adam Houghton — 1999
• Src Family Kinases Negatively Regulate Platelet-derived Growth Factor α Receptor-dependent Signaling and Disease Progression*Stephan Rosenkranz, Yasushi Ikuno, Fee Lai Leong — 2000
• The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation*Rintaro Hashizume, Mamoru Fukuda, Ichiro Maeda — 2001
• Role and Function of the 26S Proteasome in Proliferation and ApoptosisCord Naujokat, Stephan Hoffmann — 2002
• Ubiquitin and the enigma of intracellular protein degradation.Herbert P. Jennissen — 1995
• MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced ApoptosisChristian Widmann, Pär Gerwins, Nancy L. Johnson — 1998
• Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanismR. Keith Esch, B. Errede — 2002
• Inhibition of Src Family Kinases Blocks Epidermal Growth Factor (EGF)-induced Activation of Akt, Phosphorylation of c-Cbl, and Ubiquitination of the EGF Receptor*C. Kenneth Kassenbrock, Seija Hunter, Pamela J. Garl — 2002
• Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.David J. Katzmann, Markus Babst, Scott D. Emr — 2001
• The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.Michael H. Glickman, Aaron Ciechanover — 2002

Cited by

• Extracellular Ubiquitin: Role in Myocyte Apoptosis and Myocardial RemodelingStephanie L.C. Scofield, Parthiv Amin, Mahipal Singh — 2015
• Rôle du couple Flt3-ligand/Flt3 et de l'activation des "Mitogen-activated protein kinases" p38 dans la dysmégacaryopoïèse des patients atteints de myélofibrose primitiveChristophe Desterke — 2011
• Critical Kinases Required for the Proliferation and Survival of Diffuse Large B-cell LymphomaJulie Marie Matthews — 2011
• From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical ImportanceMichael Karin, Ewen Gallagher — 2005
• Analysis of the Role of Ubiquitin-interacting Motifs in Ubiquitin Binding and Ubiquitylation*[boxs]Stephanie L. Miller, Erica Malotky, John P. O’Bryan — 2004
• MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathwaySer Sue Ng, Tokameh Mahmoudi, Vivian Li — 2010
• Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity.David C. Zebrowski, Ralph R. Alcendor, Lorrie A. Kirshenbaum — 2006
• Differential regulation and properties of MAPKsMalavika Raman, W Chen, Melanie H. Cobb — 2007
• Regulating Global Sumoylation by a MAP Kinase Hog1 and Its Potential Role in Osmo-Tolerance in YeastAmeair Abu Irqeba, Yang Li, Mahmoud Panahi — 2014
• Subcellular targeting regulates the function of caspase-activated protein kinases in apoptosis.Rolf Jakobi — 2004
• Regulation of Ste7 Ubiquitination by Ste11 Phosphorylation and the Skp1-Cullin-F-box Complex*Yuqi Wang, Qing Ge, Dayle Houston — 2003
• Resonating to the music of ubiquitinationSudha K. Shenoy, Robert J. Lefkowitz — 2004
• Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokersJeffery Edmiston, Kellie J. Archer, Mariano J. Scian — 2010
• Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitinHaopeng Wang, Atsushi Matsuzawa, Scott A. Brown — 2008
• Dynamic Positive Feedback Phosphorylation of Mixed Lineage Kinase 3 by JNK Reversibly Regulates Its Distribution to Triton-soluble Domains*Karen A. Schachter, Yan Du, Anning Lin — 2006
• Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody productionEwen Gallagher, Thomas Enzler, Atsushi Matsuzawa — 2007
• Apoptosis Induced by Cytoskeletal Disruption Requires Distinct Domains of MEKK1Erin M. Tricker, Afsane Arvand, Raymond Kwan — 2011
• Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.Mark Uhlik, Amy N. Abell, Bruce D. Cuevas — 2004
• Proliferative effects of Chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent.Kun Huang, Min-Jin Lu, Yueh-Sheng Chen — 2009
• A MAP3k1 SNP Predicts Survival of Gastric Cancer in a Chinese PopulationXiaowei Wei, Enke Zhang, Chun Wang — 2014

Related papers

• The poxvirus encoded ubiquitin ligase, p28, is regulated by proteasomal degradation and autoubiquitination.Kelly Mottet, Bettina Bareiss, Craig D. Milne — 2014
• Ubiquitination and Degradation of Mutant p53Natalia Lukashchuk, Karen H. Vousden — 2007
• Promiscuous Interactions of gp78 E3 ligase CUE domain with polyubiquitin chainsShan Liu, Yinghua Chen, Jess Li — 2012
• The Antibiotic Treatment Index: A Novel Tool to Improve Antibiotic Resistance MonitoringTaweesuk Manomayitthikan, Nusaraporn Kessomboon, Glenn N. Borlace — 2014
• The Ubiquitin E3 Ligase MaLUL2 Is Involved in High Temperature-Induced Green Ripening in Banana FruitWei Wei, Jianye Chen, Ze-xiang Zeng — 2020
• Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based ProbeRahul Nair, Ayshwarya Seenivasan, Bing Liu — 2021
• Multiple E3 ligases act as antiviral factors against SARS-CoV-2 via inducing the ubiquitination and degradation of ORF9bMiao Yu, Jie Li, Wenying Gao — 2024
• Ubiquitin over-expression promotes E6AP autodegradation and reactivation of the p53/MDM2 pathway in HeLa cellsRita Crinelli, Marzia Bianchi, Michele Menotta — 2008
• Auto-ubiquitination of Mdm2 Enhances Its Substrate Ubiquitin Ligase Activity*Ruchira S. Ranaweera, Xiaolu Yang — 2013