The Folliculin tumor suppressor is a GAP for RagC/D GTPases that signal amino acid levels to mTORC1

Keywords

Folliculin, mTORC1, Biology, GTPase, Amino acid

References

• Rheb promotes cell growth as a component of the insulin/TOR signalling networkLeslie Saucedo, Xinsheng Gao, Dominic A. Chiarelli — 2003
• A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1Liron Bar‐Peled, Lynne Chantranupong, Andrew D. Cherniack — 2013
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• Identification and characterization of a novel folliculin-interacting protein FNIP2.Hisashi Hasumi, Masaya Baba, Seung‐Beom Hong — 2008
• The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All GenesMaureen E. Hillenmeyer, Eula Fung, Jan Wildenhain — 2008
• Folliculin Contributes to VHL Tumor Suppressing Activity in Renal Cancer through Regulation of AutophagyPrabhat Bastola, Yiwen Stratton, Emily Kellner — 2013
• Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survivalAlejo Efeyan, Roberto Zoncu, Steven H. Chang — 2012
• Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner*Ariel F. Castro, John F. Rebhun, Geoffrey Clark — 2003
• Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin*Andrew R. Tee, Rana Anjum, John Blenis — 2003
• Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons.Arthur R. Birt — 1977
• Novel G Proteins, Rag C and Rag D, Interact with GTP-binding Proteins, Rag A and Rag B*Takeshi Sekiguchi, Eiji Hirose, Nobutaka Nakashima — 2001
• Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapiesLaura S. Schmidt — 2012
• An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1Liron Bar‐Peled, Lawrence D. Schweitzer, Roberto Zoncu — 2012
• GEFs and GAPs: critical elements in the control of small G proteins.Johannes L. Bos, Holger Rehmann, Alfred Wittinghofer — 2007
• The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.Masaya Baba, Jonathan R. Keller, Hong‐Wei Sun — 2012
• Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2Yukiko Hasumi, Masaya Baba, Rieko Ajima — 2009
• Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.Jacob John, H. Rensland, Ilme Schlichting — 1993
• TSC2 mediates cellular energy response to control cell growth and survival.Ken Inoki, Tianqing Zhu, Kun‐Liang Guan — 2003
• Regulation of the small GTPase Rheb by amino acidsMarta Roccio, Johannes L. Bos, Fried Zwartkruis — 2006
• Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) proteinYumiko Takagi, Toshiyuki Kobayashi, Masatoshi Shiono — 2008

Cited by

• The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.Ian Stewart — 2015
• Amino acid sensing and activation of mechanistic target of rapamycin complex 1: implications for skeletal muscleDaniel J. Ham, Gordon S. Lynch, René Koopman — 2016
• Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progressionR.S. Street, T. N. Waters — 2016
• Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynaminCindi Howson — 2018
• Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membraneClaire M. Healy — 2018
• Beyond Indigestion: Emerging Roles for Lysosome-Based Signaling in Human DiseaseShawn M. Ferguson — 2015
• Molecular studies of FLCN-related diseasesMonique Luijten — 2014
• Amino acid management in cancerZhi-Yang Tsun, Richard Possemato — 2015
• The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1Shuyu Wang, Zhi-Yang Tsun, Rachel L. Wolfson — 2015
• Cellular metabolism and lysosomal mTOR signalingIsrael C. Nnah, Khoosheh Khayati, Radek Dobrowolski — 2015
• Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascadeJuan F. Linares, Ángeles Durán, Miguel Reina‐Campos — 2015
• Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent mannerPhillip T. Newton, Karuna K Vuppalapati, Thibault Bouderlique — 2015
• The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control.Sravanth K. Hindupur, Asier González, Michael N. Hall — 2015
• Folliculin, a tumor suppressor associated with Birt-Hogg-Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.Xia Qin, Guanghui Wang, Hongfeng Wang — 2016
• TOR Complexes and the Maintenance of Cellular Homeostasis.Sandra Eltschinger, Robbie Loewith — 2016
• Transcriptional and epigenetic regulation of autophagy in agingLouis R. Lapierre, Caroline Kumsta, Marco Sandri — 2015
• Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagyShintaro Kira, Keisuke Tabata, Kanae Shirahama‐Noda — 2014
• Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with FlcnHisashi Hasumi, Masaya Baba, Yukiko Hasumi — 2015
• Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans.Matthew B Carlin, Ruth Tanner, Jakob Agergaard — 2014
• Making new contacts: the mTOR network in metabolism and signalling crosstalkMitsugu Shimobayashi, Michael N. Hall — 2014

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