AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate.

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Summary

Photocross-linking studies with mouse embryonic fibroblast cell extracts indicated that APE and PARP-1 interact with the same APE-cleaved abasic site BER intermediate and that competition between these two proteins may influence their respective BER related functions.

Type
article
Published
2004-06-03
Cited by
99
References
47

Keywords

AP site, Base excision repair, AP endonuclease, DNA-(apurinic or apyrimidinic site) lyase, Poly ADP ribose polymerase

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