AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate.
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Summary
Photocross-linking studies with mouse embryonic fibroblast cell extracts indicated that APE and PARP-1 interact with the same APE-cleaved abasic site BER intermediate and that competition between these two proteins may influence their respective BER related functions.
- Type
- article
- Published
- 2004-06-03
- Cited by
- 99
- References
- 47
- OpenAlex
- https://openalex.org/W1995390673
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25438674
Keywords
AP site, Base excision repair, AP endonuclease, DNA-(apurinic or apyrimidinic site) lyase, Poly ADP ribose polymerase
References
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Cited by
- XPD DNA nucleotide excision repair gene polymorphisms associated with DNA repair deficiency predict better treatment outcomes in secondary acute myeloid leukemia
- Human base excision repair for preservation of genomic stability.
- Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair
- A review on protein–protein interaction network of APE1/Ref‐1 and its associated biological functions
- AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
- Quantitative characterization of protein–protein complexes involved in base excision DNA repair
- DNA polymerases β and λ and their roles in cell.
- The human apurinic/apyrimidinic endonuclease-1 suppresses activation of poly(adp-ribose) polymerase-1 induced by DNA single strand breaks.
- Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase beta in long patch base excision repair.
- Multifunctional human apurinic/apyrimidinic endonuclease 1: Role of additional functions
- Selected polymorphisms of DNA repair genes and risk of pancreatic cancer.
- Base excision DNA repair
- Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.
- Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.
- Ddc1 checkpoint protein and DNA polymerase ɛ interact with nick-containing DNA repair intermediate in cell free extracts of Saccharomyces cerevisiae.
- Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity
- Human RECQL5β stimulates flap endonuclease 1
- Quantitative parameters of the 3′–5′ exonuclease reaction of human apurinic/apyrimidinic endonuclease 1 with nicked DNA containing dYMP or a modified dCMP analogue
- DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase*
- Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase β and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity
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