Caveolae, lipid rafts, and vascular disease.
Explore this paper's citation graph
Summary
The physiologic importance of caveolae is evidenced by recent studies using caveolin knockout mice that show dramatic abnormalities in the cardiovascular system, such as pulmonary hypertension and cardiac hypertrophy.
- Type
- review
- Published
- 2005-04-01
- Cited by
- 99
- References
- 49
- OpenAlex
- https://openalex.org/W1995215171
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8523797
Keywords
Caveolae, Lipid raft, Caveolin, Cell biology, Caveolin 1
References
- In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
- High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
- Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
- High Density Lipoprotein-induced Endothelial Nitric-oxide Synthase Activation Is Mediated by Akt and MAP Kinases*
- Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities*
- The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles
- Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis.
- Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts.
- Plasma membrane caveolae mediate the efflux of cellular free cholesterol.
- Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.
- Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin
- A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains
- Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity*
- High Density Lipoprotein Binding to Scavenger Receptor, Class B, Type I Activates Endothelial Nitric-oxide Synthase in a Ceramide-dependent Manner*
- High Density Lipoprotein Prevents Oxidized Low Density Lipoprotein-induced Inhibition of Endothelial Nitric-oxide Synthase Localization and Activation in Caveolae*
- Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.
- VIP21/caveolin is a cholesterol-binding protein.
- Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization.
- Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin*
- Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate
Cited by
- Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability.
- Molecular Basis of Health and Disease
- Membrane lipidomics: the reorganization of fatty acids as a biomarker of cell condition
- PROTECTION AGAINST ENDOTHELIAL INFLAMMATION BY GREEN TEA FLAVONOIDS
- Hyaluronan regulation of vascular integrity.
- Interaction between p85 and Rab5 in the presences and absence of phosphorylated PDGFR peptide
- Pulmonary Vascular Disease Related to Hemodynamic Stress in the Pulmonary Circulation
- The polyphenols resveratrol and caffeic acid phenethyl ester: their influence on growth-related signaling pathways in vascular smooth muscle cells
- Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension.
- Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis*
- The Tragedy of TRIUMPH for Nitric Oxide Synthesis Inhibition in Cardiogenic Shock
- Vascular signaling through cholesterol-rich domains: implications in hypertension
- Localisation of caveolin in mammary tissue depends on cell type
- The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells.
- Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice
- The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells.
- Cell surface F1Fo ATP synthase: a new paradigm?
- Proteomic identification of proteins translocated to membrane microdomains upon treatment of fibroblasts with the glycosphingolipid, C8‐β‐D‐lactosylceramide
- Dynamin 2 and c-Abl Are Novel Regulators of Hyperoxia-mediated NADPH Oxidase Activation and Reactive Oxygen Species Production in Caveolin-enriched Microdomains of the Endothelium*
- Lipid mediators in membrane rafts are important determinants of human health and disease.
Related papers
- A second protein marker of caveolae: caveolin-2.
- Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae
- Methods for the study of signaling molecules in membrane lipid rafts and caveolae.
- Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease.
- Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae.
- Caveolae and Lipid Rafts: G Protein‐Coupled Receptor Signaling Microdomains in Cardiac Myocytes
- Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae.
- Accumulation of molecules involved in alpha1-adrenergic signal within caveolae: caveolin expression and the development of cardiac hypertrophy.
- M‐caveolin, a muscle‐specific caveolin‐related protein