Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
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Summary
In eight of the nine cases, the ras mutations were detectable in DNA purified from the stool, indicating that colorectal tumors can be detected by a noninvasive method based on the molecular pathogenesis of the disease.
- Type
- article
- Published
- 1992-04-03
- Cited by
- 749
- References
- 30
- OpenAlex
- https://openalex.org/W1995134833
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12919088
Keywords
Colorectal cancer, Pathogenesis, Oncogene, Metastasis, Mutation
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Cited by
- K-ras mutations in colorectal cancer: a practice changing discovery.
- Prevention of Colorectal Cancer by Endoscopic Polypectomy
- 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
- Advances in molecular genetics.
- Molecular advances in the etiology and treatment of colorectal cancer.
- Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction.
- Quantification of human DNA in feces as a diagnostic test for the presence of colorectal cancer.
- Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines.
- Enhanced retrieval of DNA from human fecal samples results in improved performance of colorectal cancer screening test.
- LigAmp for sensitive detection of single-nucleotide differences
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- Screening and Diagnosis for Colorectal Cancer: Present and Future
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- Nucleic Acid Based Techniques for the Detection of Rare Cancer Cells in Clinical Samples
- Genetic Defects as Tumor Markers
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- K-ras mutation and pancreatic adenocarcinoma
- From dinosaurs to DNA: a history of colorectal cancer
- Colorectal Cancer Risk: The Impact of Evidence of a Field Effect of Carcinogenesis on Blinded Diagnosis Using an Anti-Adenoma Antibody Test Performed on Colonoscopic Effluent
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