Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes.
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Summary
Through the identification of the intracellular defects in insulin action that control glucose homoeostasis, a better understanding of the disease pathogenesis can be gained and strategies for intervention may be developed.
- Type
- review
- Published
- 2005-04-01
- Cited by
- 236
- References
- 48
- OpenAlex
- https://openalex.org/W1994470496
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5683378
Keywords
Skeletal muscle, Endocrinology, Insulin resistance, Internal medicine, Insulin
References
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- The Effects of Wortmannin on Rat Skeletal Muscle
- Diabetes mellitus: theory and practice
- Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle.
- Mechanism of activation of protein kinase B by insulin and IGF‐1.
- Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
- Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
- Glucose transport into rat skeletal muscle: interaction between exercise and insulin.
- Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.
- The insulin signalling system and the IRS proteins
- A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in Vivo*
- Role of IRS-2 in insulin and cytokine signalling
- Differential regulation of two distinct glucose transporter species expressed in 3T3-L1 adipocytes: effect of chronic insulin and tolbutamide treatment.
- Insulin receptor substrate proteins and neuroendocrine function.
- Akt Signaling--Linking Membrane Events to Life and Death Decisions
- Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation*
- Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.
- Insulin Receptor as a Tyrosine Protein Kinase a
- Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
Cited by
- The metabolic syndrome: role of skeletal muscle metabolism.
- Acute Oxidative Stress Can Reverse Insulin Resistance by Inactivation of Cytoplasmic JNK*
- Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus
- The potential beneficial role of isoflavones in type 2 diabetes mellitus.
- Investigating GLUT4 Trafficking in Muscle
- Putative role of palmitate and Akt signaling in attenuating skeletal muscle growth in the obese zucker rat
- Characterization of the insulin signalling pathways in skeletal muscle and skin of streptozotocin-induced diabetic male Sprague-Dawley rats : the effects of oleanolic acid.
- Skeletal muscle metabolic flexibility: contribution of genetics and lifestyle
- The role of PtdIns(4,5)P2 and its regulatory proteins in the development of insulin resistance in cell culture models
- Therapeutic interventions for lipid-induced insulin resistance in skeletal muscle: mechanisms of action
- Glucose and lipid metabolism in human skeletal muscle
- REFEIÇÕES RICAS EM CARBOIDRATOS OU LIPÍDEOS DIMINUEM A SENSIBILIDADE À INSULINA DUAS HORAS APÓS O INÍCIO DA INGESTÃO
- The role of FTO, ENPP1 and TCF7L2 in the pathogenesis of diabetes in an adult population from Bellville South, Cape Town, South Africa
- Interleukin-6 and insulin resistance.
- Mechanisms of hexosamine-induced cholesterol accumulation and therapeutic actions of chromium
- NESFATIN-1 AND NESFATIN-1-LIKE PEPTIDE: NUCLEOBINDIN-1/2-ENCODED INSULINOTROPIC AND ENTEROTROPIC PEPTIDES
- Gene expression in human skeletal muscle : Effects of activity, fibre type and inheritance for diabetes
- Insulin-like growth factor binding protein-3 : structure and function
- ESTROGEN RECEPTOR REGULATION OF GLUCOSE AND FAT METABOLISM IN THE SKELETAL MUSCLE AND ADIPOSE TISSUE
- Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle.
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