Roles of Hematopoietic Transcription Factors GATA-1 and GATA-2 in the Development of Red Blood Cell Lineage
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Summary
Gene ablation studies in mouse revealed a cross-regulatory mechanism by which GATA-1 can control the expression of Gata-2 and vice versa, possibly via essential GATA binding sites in their cis-acting elements.
- Type
- review
- Published
- 2002-11-01
- Cited by
- 216
- References
- 35
- OpenAlex
- https://openalex.org/W1992621257
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29966039
Keywords
GATA2, GATA transcription factor, Haematopoiesis, GATA1, Transcription factor
References
- The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region.
- GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies.
- Delta-thalassemia caused by disruption of the site for an erythroid-specific transcription factor, GATA-1, in the delta-globin gene promoter.
- Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system
- Regulation of activity of the transcription factor GATA-1 by acetylation
- Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.
- Identification of human GATA-2 gene distal IS exon and its expression in hematopoietic stem cell fractions.
- A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.
- Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis
- A new PKLR gene mutation in the R‐type promoter region affects the gene transcription causing pyruvate kinase deficiency
- Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
- The erythroid-specific transcription factor Eryf1: a new finger protein.
- Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation.
- X-linked thrombocytopenia caused by a novel mutation of GATA-1.
- Structure and promoter activity of the gene for the erythroid transcription factor GATA-1.
- Arrest in Primitive Erythroid Cell Development Caused by Promoter-specific Disruption of the GATA-1 Gene*
- An early haematopoietic defect in mice lacking the transcription factor GATA-2
- Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.
- Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia.
- Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
Cited by
- GATA transcription factors in the developing reproductive system.
- Endothelium as an organ system.
- Value of GATA3 Immunostaining in Tumor Diagnosis: A Review
- Computational Detection of Stage-Specific Transcription Factor Clusters during Heart Development
- Cochlear neurosensory specification and competence: you gata have Gata
- Stepwise commitment from embryonic stem to hematopoietic and endothelial cells.
- Hsp70 est un nouveau régulateur majeur de l'érythropoïèse empêchant le clivage du facteur de transcription GATA-1 par la caspase-3 au cours de la différenciation.
- Lineage relationship analysis of lymphoid progenitor subsets in the bone marrow of naïve mice and during inflammation
- Etude des mécanismes cellulaires et moléculaires de l'inhibition de l'érythropoïèse par la cytokine pro-inflammatoire Tumor necrosis factor (TNF)-alpha
- Computational models of intracellular and intercellular processes in developmental biology
- Rapid turnover of GATA‐2 via ubiquitin‐proteasome protein degradation pathway
- STAT3 and STAT5 signaling in normal and leukemic hematopoietic cells
- Transgenic over‐expression of GATA‐1 mutant lacking N‐finger domain causes hemolytic syndrome in mouse erythroid cells
- CYP2C19 and CYP2C9 : New aspects of pharmacogenetics and transcriptional regulation
- Contribution of the GATA2 transcription factor to the development and progression of myeloid disorders
- Polycythemia following allogeneic hematopoietic progenitor cell transplantation occurring during iron chelation therapy
- ApiAP2 Factors as Candidate Regulators of Stochastic Commitment to Merozoite Production in Theileria annulata
- The Role of GATA in Mammalian Reproduction
- Prediction of transcription factor co-occurrence using rank based statistics
- Characterization of human myeloid progenitors and their differentiation
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