miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation
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Summary
It is demonstrated that miR-31 upregulated IL-2 expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation.
- Type
- article
- Published
- 2013-01-10
- Cited by
- 33
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W1992597662
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9715736
Keywords
Jurkat cells, Biology, Gene knockdown, Ectopic expression, T cell
References
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- Let-7/miR-98 regulate Fas and Fas-mediated apoptosis
- Cot, a novel kinase of histone H3, induces cellular transformation through up‐regulation of c‐fos transcriptional activity
- MicroRNAs and Their Emerging Roles in Immunology
- Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation
- Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation*
- MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.
- T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
- Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling*
- Aberrant T cell differentiation in the absence of Dicer
- Human natural Treg microRNA signature: Role of microRNA‐31 and microRNA‐21 in FOXP3 expression
- MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/interferon gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity
- Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis
- Processing of primary microRNAs by the Microprocessor complex
- miRNA Profiling of Naïve, Effector and Memory CD8 T Cells
- MicroRNAs
Cited by
- Function and Regulation of MicroRNA-31 in Development and Disease
- From cell biology to immunology: Controlling metastatic progression of cancer via microRNA regulatory networks
- T-cell Activation Induces Dynamic Changes in miRNA Expression Patterns in CD4 and CD8 T-cell Subsets.
- Sex differences and estrogen regulation of miRNAs in lupus, a prototypical autoimmune disease.
- Cross‐regulation between cytokine and microRNA pathways in T cells
- miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4+ T Cells
- microRNAs and the mammary gland: A new understanding of gene expression
- MicroRNA Regulation in Systemic Lupus Erythematosus Pathogenesis
- Characterization of microRNAs differentially expressed during bovine follicle development.
- Immuno‐miRs: critical regulators of T‐cell development, function and ageing
- ARG-walker: inference of individual specific strengths of meiotic recombination hotspots by population genomics analysis
- Altered microRNA Expression and Immunosuppressive Cytokine Production by Regulatory T Cells of Ulcerative Colitis Patients
- Effect of tumor necrosis factor-α induced protein 8 like-2 on immune function of dendritic cells in mice following acute insults
- Characteristics of TCRζ, ZAP-70, and FcɛRIγ Gene Expression in Patients with T- and NK/T-Cell Lymphoma
- The role of microRNA-31 and microRNA-21 as regulatory biomarkers in the activation of T lymphocytes of Egyptian lupus patients
- Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection
- The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
- Identification of aminosulfonylarylisoxazole as microRNA-31 regulators
- MicroRNA 31 inhibits CD8+ T-cell function by increasing its sensitivity to type I interferon signaling in chronic viral infection
- Hitting the brake: miR-31 regulates CD8 T cell effector function
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