Making crossovers during meiosis.
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Summary
This work has shown that there are at least two pathways for generating crossovers in meiotic recombination, and one pathway involves the resolution of fully ligated four-way DNA junctions [HJs (Holliday junctions)] by an as yet unidentified endonuclease.
- Type
- article
- Published
- 2005-10-26
- Cited by
- 150
- References
- 67
- OpenAlex
- https://openalex.org/W1991971470
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11064766
Keywords
Meiosis, Biology, Genetics, Evolutionary biology, Gene
References
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- Mammalian MutS homologue 5 is required for chromosome pairing in meiosis
- The X philes: structure‐specific endonucleases that resolve Holliday junctions
- Fission yeast Mus81.Eme1 Holliday junction resolvase is required for meiotic crossing over but not for gene conversion.
- The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.
- A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae.
- hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes.
- The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination.
- Cleavage of Model Replication Forks by Fission Yeast Mus81-Eme1 and Budding Yeast Mus81-Mms4
- The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis
- MSH4 acts in conjunction with MLH1 during mammalian meiosis
- Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site.
- Double-strand breaks at an initiation site for meiotic gene conversion
- Meiotic recombination: sealing the partnership at the junction.
- Identification and Characterization of the Human Mus81-Eme1 Endonuclease*
- Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.
- The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions.
- Imposition of crossover interference through the nonrandom distribution of synapsis initiation complexes.
- Saccharomyces cerevisiae Mer3 helicase stimulates 3'-5' heteroduplex extension by Rad51; implications for crossover control in meiotic recombination.
- The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10
Cited by
- Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks.
- Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases.
- Targeted meiotic recombination in Arabidopsis thaliana
- XRCC1, un élément clef de la réparation des dommages de l'ADN couplée à la réplication
- Radiosensibilisierung durch epigenetisch modifizierende Substanzen in humanen Normalgewebszellen
- The early evolution of meiotic genes
- Meiotic chromosome pairing in C. elegans
- Novel Roles of Replication Protein A Phosphorylation in the Cellular Response to DNA Damage
- Analysis Of Natural Variation In Recombination In Maize
- Regulation of activation induced deaminase
- Investigating the Roles of NDJ1 and TID1 in Distributive Segregation Using Non-Exchange Chromosomes
- Contrasted patterns in mating-type chromosomes in fungi: hotspots versus coldspots of recombination
- Telomeres and meiosis in health and disease
- Genome structure and pathogenicity of the fungal wheat pathogen Mycosphaerella graminicola
- Meiotic chromosome dynamics
- The meiotic recombination hotspots of Schizosaccharomyces pombe.
- The interplay between chromosome structure and meiotic integrity
- Meiotic recombination and crossovers in plants.
- Sumoylation regulates EXO1 stability and processing of DNA damage
- Analysis of stem cell genome stability and cancer-associated developmental programmes
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