Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo
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Summary
Monitoring of the rheological effects of hydroxyurea (HU) on erythrocytes obtained from two patients with severe sickle cell anemia indicates that, in addition to its effect on the production of Hb F, HU has a salutary effect on whole cell deformability and on the hydration status of sickle ery Throcytes.
- Type
- article
- Published
- 1989-10-01
- Cited by
- 149
- References
- 32
- OpenAlex
- https://openalex.org/W1990982927
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38878465
Keywords
Sickle cell anemia, Mean corpuscular volume, In vivo, Centrifugation, Erythrocyte deformability
References
- A simple laboratory alternative to irreversibly sickled cell (ISC) counts.
- Estimation of Small Percentages of Fœtal Hæmoglobin
- Volumetric erythrocyte macrocytosis induced by hydroxyurea.
- The effect of hydroxyurea on hemoglobin F in patients with myeloproliferative syndromes.
- New optical technique for measuring erythrocyte deformability with the ektacytometer.
- Erythrocytes in Hb SC disease are microcytic and hyperchromic
- Study on the dehydrating effect of the red cell Na+/K+-pump in nystatin-treated cells with varying Na+ and water contents.
- A clinically significant anti‐N in a patient whose red cells were negative for N and U antigens
- Modulation of membrane protein lateral mobility by polyphosphates and polyamines.
- Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S.
- Insertion of synthetic copies of human globin genes into bacterial plasmids.
- Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea.
- Diagnostic Laboratory Hematology
- Adhesivity and rigidity of erythrocyte membrane in relation to wheat germ agglutinin binding
- Deformability of isolated red blood cell membranes.
- Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.
- Detection of specific sequences among DNA fragments separated by gel electrophoresis.
- Stabilization of erythrocyte membranes by polyamines.
- Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations
- Erythrocyte membrane rigidity induced by glycophorin A-ligand interaction. Evidence for a ligand-induced association between glycophorin A and skeletal proteins.
Cited by
- Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea.
- Sickle Cell Disease Erythrocyte Stiffness and Cytoadhesion Investigated via Atomic Force Microscopy
- Mechanism of action of hydroxyurea.
- Treatment of myeloproliferative disorders with hydroxyurea: effects on red blood cell geometry and deformability.
- An overview of the clinical experience with hydroxyurea.
- Hydroxyurea and erythropoietin therapy in sickle cell anemia.
- RheothRx (poloxamer 188) injection for the acute painful episode of sickle cell disease: a pilot study.
- Rheology of red blood cells in patients with HbC disease
- Induction of fetal hemoglobin in sickle cell disease.
- Histamine as a Potential Initiator of Sickle Pain crisis by Mediation of Sickle Erythrocyte Adherence in a Shear-Dependent Manner
- Impaired oxygen uptake efficiency slope and off-transient kinetics of pulmonary oxygen uptake in sickle cell anemia are associated with hemorheological abnormalities
- K transport and red cell dehydration in sickle and normal erythrocytes
- Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.
- Erythrocyte deformability and aggregation in homozygous sickle cell disease
- A bioavailability and pharmacokinetic study of oral and intravenous hydroxyurea.
- Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea
- Hydroxyurea affects cell morphology, cation transport, and red blood cell adhesion in cultured vascular endothelial cells.
- 鎌状赤血球(sickle cell)のレオロジー
- Atomic Force Microscopy in Biomedical Research
- Red blood cell changes during the evolution of the sickle cell painful crisis.
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