Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses
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Summary
Hypoxia can elicit effects of phosphorylation-dependent degradation of the IFNAR1 chain of the Type 1 interferon (IFN) receptor in a PERK-dependent manner and enables multiple cellular components of tumor tissue to evade the direct and indirect anti-tumorigenic effects of Type 1 IFN.
- Type
- article
- Published
- 2012-10-08
- Cited by
- 71
- References
- 55
- OpenAlex
- https://openalex.org/W1990340716
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10202700
Keywords
Biology, Protein kinase R, Integrated stress response, Kinase, EIF-2 kinase
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Cited by
- Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment
- Tumor progression and the Different Faces of the PERK kinase
- ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.
- Type 1 interferons contribute to the clearance of senescent cell
- Eliminative signaling by Janus kinases: role in the down-regulation of associated receptors
- Regulation of type I interferon responses
- Metabolic control of tumor progression and anti-tumor immunity
- UPR, autophagy and mitochondria crosstalk underlies the ER stress response
- Hope and Fear for Interferon: The Receptor-Centric Outlook on the Future of Interferon Therapy
- Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
- Anti-metastatic functions of type 1 interferons: Foundation for the adjuvant therapy of cancer
- Optimizing mouse models for precision cancer prevention
- Type I interferons mediate pancreatic toxicities of PERK inhibition
- Quality control of Gardeniae Fructus by HPLC-PDA fingerprint coupled with chemometric methods.
- Suppression of type I interferon signaling overcomes oncogene-induced senescence and mediates melanoma development and progression
- BRAF Inhibitors and IFNα: Plus, Minus, or Indeterminate?
- Therapeutic elimination of the type 1 interferon receptor for treating psoriatic skin inflammation
- SnapshotDx Quiz: October 2016.
- A potent in vivo anti-tumor efficacy of novel recombinant type I interferon
- Role of interferon in melanoma: old hopes and new perspectives
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