C-H bond activation enables the rapid construction and late-stage diversification of functional molecules.
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Summary
This Perspective highlights the potential of metal-catalysed C-H bond activation reactions, which now extend beyond the field of traditional synthetic organic chemistry, and are more atom- and step-economical than previous methods.
- Type
- article
- Published
- 2013-05-01
- Cited by
- 1,882
- References
- 55
- OpenAlex
- https://openalex.org/W1989688131
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22652795
Keywords
Chemistry, Diversification (marketing strategy), Organic molecules, Organic synthesis, Biochemical engineering
References
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- Pd(OAc)2/o-chloranil/M(OTf)n: a catalyst for the direct C-H arylation of polycyclic aromatic hydrocarbons with boryl-, silyl-, and unfunctionalized arenes.
- Highly efficient incorporation of functional groups into aromatic main-chain polymer using iridium-catalyzed C-H activation and suzuki-miyaura reaction.
- Synthesis of silafluorenes by iridium-catalyzed [2 + 2 + 2] cycloaddition of silicon-bridged diynes with alkynes.
- Fluorescent diarylindoles by palladium-catalyzed direct and decarboxylative arylations of carboxyindoles.
- Controlled Functionalization of Crystalline Polystyrenes via Activation of Aromatic C-H Bonds †
- Postsynthetic methods for the functionalization of metal-organic frameworks.
- Palladium-catalyzed C-H bond functionalization of a metal-organic framework (MOF): mild, selective, and efficient.
- Regioselective Ru-catalyzed direct 2,5,8,11-alkylation of perylene bisimides.
- From C(sp2)-H to C(sp3)-H: systematic studies on transition metal-catalyzed oxidative C-C formation.
- Exploitation of an additional hydrophobic pocket of σ1 receptors: late-stage diverse modifications of spirocyclic thiophenes by C-H bond functionalization.
- Palladium-catalysed direct arylation of a tris-cyclometallated Ir(III) complex bearing 2,2'-thienylpyridine ligands: a powerful tool for the tuning of luminescence properties.
- Thermal, catalytic, regiospecific functionalization of alkanes
- Rhodium-Catalyzed C-C Bond Formation via Heteroatom-Directed C-H Bond Activation
- Recent developments in natural product synthesis using metal-catalysed C-H bond functionalisation.
- Palladium-Catalyzed Ligand-Directed C–H Functionalization Reactions
- Late-Stage C–H Bond Arylation of Spirocyclic σ1 Ligands for Analysis of Complementary σ1 Receptor Surface
- C-H activation: a complementary tool in the total synthesis of complex natural products.
- Rhodium-catalyzed, regiospecific functionalization of polyolefins in the melt.
Cited by
- Modular assembly of ring-fused and π-extended phenanthroimidazoles via C-H activation and alkyne annulation.
- Efficient synthesis of π-extended phenazasilines for optical and electronic applications.
- Rhodium(III)-catalyzed C-H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles.
- Cobalt(III)-Catalyzed Aryl and Alkenyl C-H Aminocarbonylation with Isocyanates and Acyl Azides.
- Cp*Co(III) Catalyzed Site-Selective C-H Activation of Unsymmetrical O-Acyl Oximes: Synthesis of Multisubstituted Isoquinolines from Terminal and Internal Alkynes.
- Cp*Co(III) -Catalyzed C(sp(3) )-H Bond Amidation of 8-Methylquinoline.
- Asymmetric Iron-Catalyzed C-H Alkylation Enabled by Remote Ligand meta-Substitution.
- Halo-substituted benzenesulfonyls and benzenesulfinates: convenient sources of arenes in metal-catalyzed C-C bond formation reactions for the straightforward access to halo-substituted arenes.
- Direct C-H Carbamoylation of Nitrogen-Containing Heterocycles.
- Cp*CoIII-Catalyzed Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Alkylquinolines with Maleimides.
- Photocatalytic C-H Activation with Alcohol as a Hydrogen Atom Transfer Agent in a 9-Fluorenone Based Metal-Organic Framework.
- Catalysts for C–H functionalization: Platinum, gold and even nanodiamonds
- Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation.
- Rh(III)-catalyzed aromatic C–H bond carbenoid functionalization of triazenes by α-diazomalonate
- A Unique Alkylation of Azobenzenes with Allyl Acetates by Rh(III)-Catalyzed C-H Functionalization.
- Oxidative Heterocycle Formation Using Hypervalent Iodine(III) Reagents.
- Bidentate ligand 8-aminoquinoline-aided Pd-catalyzed diastereoselective β-arylation of the prochiral secondary sp3 C–H bonds of 2-phenylbutanamides and related aliphatic carboxamides
- Cu-Catalyzed Cyanation of Indoles with Acetonitrile as a Cyano Source.
- Iridium(III)-catalyzed direct arylation of C-H bonds with diaryliodonium salts.
- Ruthenium‐Catalyzed Alkenylation of Arenes with Alkynes or Alkenes by 1,2,3‐Triazole‐Directed C–H Activation
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