Integrated THz technology for label-free genetic diagnostics
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Summary
This work reports on a promising approach for the label-free analysis of DNA molecules using direct probing of the binding state of DNA with electromagnetic waves at THz frequencies that provides a drastically enhanced sensitivity enabling analysis down to femtomol levels.
- Type
- article
- Published
- 2002-01-02
- Cited by
- 531
- References
- 17
- OpenAlex
- https://openalex.org/W1989066746
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35340836
Keywords
Terahertz radiation, Resonator, Planar, Optoelectronics, Molecular biophysics
References
- Microwave Filters, Impedance-Matching Networks, and Coupling Structures
- Self-consistent calculation of localized DNA vibrational properties at a double-helix-single-strand junction with anharmonic potential.
- Molecular mechanism controlling the incorporation of fluorescent nucleotides into DNA by PCR.
- Kinetics of renaturation of DNA.
- The estimation of distances between specific backbone-labeled sites in DNA using fluorescence resonance energy transfer.
- Accessing Genetic Information with High-Density DNA Arrays
- Low-dispersion thin-film microstrip lines with cyclotene (benzocyclobutene) as dielectric medium
- Label-Free Probing of the Binding State of DNA by Time-Domain Terahertz Sensing
- Low Frequency Raman Spectra of DNA
- Investigation of far-infrared vibrational modes in polynucleotides.
- Low-lying collective modes of DNA double helix by Raman spectroscopy.
- Optoelectronic on-chip characterization of ultrafast electric devices: Measurement techniques and applications
- From DNA biosensors to gene chips.
- Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz
- Full-wave analysis of a split-cylinder resonator for nondestructive permittivity measurements
- Comparison of fluorescein isothiocyanate- and Texas red-conjugated nucleotides for direct labeling in comparative genomic hybridization.
Cited by
- Propagation of terahertz radiation in non-homogeneous materials and structures
- Label-free probing of genes by time-domain terahertz sensing.
- On-Chip THz Detection of Biomaterials: A Numerical Study
- Reflective terahertz tunable polarization controller
- Surface waves on two-dimensional rough Neumann surfaces
- Investigation of slit-type wiggler parameters for a free electron LASER module
- Terahertz time-domain spectroscopy and imaging of DNA
- Determination of resonant frequencies for DNA and protein by directly measuring absorption spectra
- Evaluation of trace amounts of liquid using THz waves
- Application of narrowband tunable THz-radiation for biomedical sensing
- A Low-Loss Terahertz Fiber With Crossed Rectangular Shaped Dielectric Strips
- Imaging and astronomy share new wave
- Broadband on-chip terahertz spectroscopy
- Recent progress of terahertz imaging technology
- Cavity Enhanced THz Generation in Nonlinear Crystals Pumped by Near-IR Fiber Lasers
- Characteristics of THz waves and carrier scattering in boron-doped epitaxial Si and Si1−xGex films
- Propagation Through Terahertz Waveguides with Photonic Crystal Boundaries
- Far-infrared spectroscopy of hydrogen bonding in nucleobases, nucleosides, and nucleotides
- Ultrafast Phenomena in Semiconductors and Nanostructure Materials XII
- Terahertzfeld-induzierte Stoßionisationslawinen in GaAs
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