Neurons in medial prefrontal cortex signal memory for fear extinction
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Summary
It is suggested that consolidation of extinction learning potentiates infralimbic activity, which inhibits fear during subsequent encounters with fear stimuli, indicating that medial prefrontal cortex might store long-term extinction memory.
- Type
- article
- Published
- 2002-11-07
- Cited by
- 1,861
- References
- 56
- OpenAlex
- https://openalex.org/W1989045560
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18806875
Keywords
Extinction (optical mineralogy), Infralimbic cortex, Neuroscience, Prefrontal cortex, Psychology
References
- Two different lateral amygdala cell populations contribute to the initiation and storage of memory
- Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
- Higher Brain Blood Flow at Amygdala and Lower Frontal Cortex Blood Flow in PTSD Patients with Comorbid Cocaine and Alcohol Abuse Compared with Normals
- Bistable Behavior of Inhibitory Neurons Controlling Impulse Traffic through the Amygdala: Role of a Slowly Deinactivating K+ Current
- The amygdala modulates prefrontal cortex activity relative to conditioned fear
- Biogeography and Ecological Setting of Indian Ocean Hydrothermal Vents
- Are vent shrimps blinded by science?
- Light at deep‐sea hydrothermal vents
- Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.
- Radiometric ages of brachyuran crabs from the Galapagos spreading‐center hydrothermal ventfield
- Wax-ester reserves facilitate dispersal of hydrothermal vent shrimps
- Development and behavior of megalopa larvae and juveniles of the hydrothermal vent crab Bythograea thermydron
- The endogenous cannabinoid system controls extinction of aversive memories
- Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study.
- Development of brain stimulation reward in the medial prefrontal cortex: facilitation by prior electrical stimulation of the sulcal prefrontal cortex.
- Electrophysiological study of the response of medial prefrontal cortex neurons to stimulation of the basolateral nucleus of the amygdala in the rat.
- The sight of deep wet heat
- Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat.
- The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat.
- An fMRI study of anterior cingulate function in posttraumatic stress disorder.
Cited by
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- Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear.
- Mechanisms of exposure therapy: how neuroscience can improve psychological treatments for anxiety disorders.
- Psychobiology of Mindfulness
- Eyes Wide Shut: Amygdala Mediates Eyes-Closed Effect on Emotional Experience with Music
- Negative affective pictures can elicit physical symptoms in high habitual symptom reporters
- M-Type Potassium Channels Modulate the Intrinsic Excitability of Infralimbic Neurons and Regulate Fear Expression and Extinction
- The effects of muscimol and AMN082 injections into the medial prefrontal cortex on the expression and extinction of conditioned fear in mice
- Prelimbic and Infralimbic Neurons Signal Distinct Aspects of Appetitive Instrumental Behavior
- Cannabinoid Modulation of Fear Extinction Brain Circuits: A Novel Target to Advance Anxiety Treatment
- Amygdala-cingulate intrinsic connectivity is associated with degree of social inhibition
- Roles of the endocannabinoid system in learning and memory.
- Exposure to an Obesogenic Diet During Adolescence Leads to Abnormal Maturation of Neural and Behavioral Substrates Underpinning Fear and Anxiety
- Chronic nicotine exposure in pre-adolescence enhances later spontaneous recovery of fear memory
- Extinction learning as a potential mechanism linking high vagal tone with lower PTSD symptoms among abused youth
- Altered functional connectivity in the fear network of firefighters with repeated traumatic stress.
- Beyond neurons: The role of the oligodendrocyte-specific gene CNP1 in major depressive disorder
- Why laterality matters in trauma: sinister aspects of memory and emotion
- Erasing Fear : Effect of Disrupting Fear Memory Reconsolidation on Central and Peripheral Nervous System Activity
- The Neurosteroids Allopregnanolone and DHEA Modulate Neurocircuits implicated in Emotion Regulation and Posttraumatic Stress Disorder.
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