Dynorphin induces partially reversible paraplegia in the rat.
Explore this paper's citation graph
Summary
Dynorphin administered intrathecally causes dose-related, partially reversible, hindlimb paralysis in the unanesthetized rat, suggesting that dynorphin or Dynorphin-related peptides may play a role in spinal cord injury.
- Type
- article
- Published
- 1983-07-22
- Cited by
- 75
- References
- 9
- OpenAlex
- https://openalex.org/W1988765394
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4597810
Keywords
Dynorphin, Opioid peptide, Paraplegia, Spinal cord, Medicine
References
- Multiple opiate binding sites in rat spinal cord.
- Evidence for an involvement of mu-, but not delta- or kappa-opiate receptors in sympathetically and parasympathetically mediated cardiovascular responses to opiates upon anterior hypothalamic injection.
- Multiple opiate receptors in peripheral tissue preparations.
- Endorphins in experimental spinal injury: Therapeutic effect of naloxone
- Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
- Effect of naloxone on posttraumatic ischemia in experimental spinal contusion.
- Chronic catheterization of the spinal subarachnoid space.
- Nonopiate effects of dynorphin and des-Tyr-dynorphin.
Cited by
- Behavioral effects of centrally administered dynorphin and [D-ala2-D-leu] enkephalin (DADLE) in rats.
- New Pharmacologic Approaches to Spinal Cord Injury: Opiate Antagonists and Thyrotropin-Releasing Hormone
- Studies of the release of immunoreactive galanin and dynorphin A(1-8) in the spinal cord of the rat.
- Neurotisation du plexus lombo-sacré, à l'aide de greffons nerveux périphériques de nerfs inter-costaux, chez le chien
- Pathobiology of dynorphins in trauma and disease.
- Influence of dynorphin A antibodies on the formation of edema and cell changes in spinal cord trauma.
- Pathophysiology of the Blood–Spinal Cord Barrier in Traumatic Injury
- New Pharmacologic Approaches to Acute Spinal Cord Injury
- Dynorphin A content in the rat brain and spinal cord after a localized trauma to the spinal cord and its modification with p-chlorophenylalanine. An experimental study using radioimmunoassay technique.
- Endopeptidase 24.15 inhibition and opioid antinociception
- N-methyl-D-aspartate (NMDA) and opioid receptors mediate dynorphin-induced spinal cord injury: behavioral and histological studies.
- Perivascular Expression and Potent Vasoconstrictor Effect of Dynorphin A in Cerebral Arteries
- Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat.
- Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity.
- Dynorphin‐related peptides cause motor dysfunction in the rat through a non‐opiate action
- Neuropeptides and central nervous system injury. Clinical implications.
- Endogenous opioid immunoreactivity in rat spinal cord following traumatic injury
- Clonidine, administered intracerebroventricularly in mice, produces an anti-analgesic effect which may be mediated spinally by dynorphin A (1-17).
- Species differences in the behavioral toxicity produced by intrathecal substance P antagonists: relationship to analgesia.
- Traumatic injury alters opiate receptor binding in rat spinal cord
Related papers
- Dynorphin, an endogenous stimulator of feeding.
- [Interaction of endogenous opioid peptides with the function of the hypothalamo-hypophyseal-testicular axis].
- Dynorphin (1-13) effects on thyrotrophin-releasing hormone and thyrotrophin secretion in rats.
- Evidence for the involvement of endogenous opioids in the inhibition of luteinizing hormone by corticotropin-releasing factor.
- Consequence of dynorphin-A administration on anterior pituitary hormone concentrations in the adult male rhesus monkey.
- [Stress and the endogenous opioid system. II. Stress, stress models and endogenous opioid peptides].
- Does Dynorphin Play a Role in the Onset of Puberty in Female Sheep?
- Endogenous opioid regulation of pulsatile luteinizing hormone secretion during sexual maturation in the female sheep.