Development of anticancer drugs based on the hallmarks of tumor cells
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Summary
This review addresses the currently available cancer drugs and development of new drugs from the perspective of their interaction with these hallmarks as well as the pathways and mechanisms involved.
- Type
- review
- Published
- 2014-01-29
- Cited by
- 41
- References
- 192
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988650737
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15763337
Keywords
Cancer, Disease, Cancer cell, Biology, Medicine
References
- Aurora Kinases as Anticancer Drug Targets
- Metastasis: from dissemination to organ-specific colonization
- Immunomodulating antibodies and drugs for the treatment of hematological malignancies
- Neutralizing endogenous chemokines with small molecules
- Genomic instability — an evolving hallmark of cancer
- The potential of TRAIL for cancer chemotherapy
- The biochemistry of apoptosis
- Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.
- Antibodies and cancer therapy: versatile platforms for cancer immunotherapy
- Oncogenes and tumour suppressors take on centrosomes
- TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies
- Anticancer strategies involving the vasculature
- ERBB Receptors and Cancer: The Complexity of Targeted Inhibitors
- Antitumor Activity of a Combination of rAd2p53 Adenoviral Gene Therapy and Radiotherapy in Esophageal Carcinoma
- DNA damage checkpoints in mammals.
- Potential of the Synthetic Lethality Principle
- Survivin in Solid Tumors: Rationale for Development of Inhibitors
- Outcome of Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Flavopiridol: Impact of Genetic Features
- Apoptosis-based therapies and drug targets
- The hallmarks of cancer
Cited by
- Medicinal plants of Ecuador: a review of plants with anticancer potential and their chemical composition
- Using Cellular Automata and Lattice Boltzmann Methods to Model Cancer Growth: Analysis of Combination Treatment Outcomes
- Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies.
- Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation
- Small molecules that affect the p53 pathway and their potential use in the treatment of cancer
- Phytochemical study and evaluation of cytotoxic and genotoxic properties of extracts from Clusia latipes leaves
- Predicting chemotherapeutic drug combinations through gene network profiling
- Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections.
- Overview of Research and Development for Anticancer Drugs
- Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression
- Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies
- Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.
- Development of 3D cancer cell models for pre-clinical research : evaluation of the tumour microenvironment in 3D stirred-systems
- A Novel Fully Human Agonistic Single Chain Fragment Variable Antibody Targeting Death Receptor 5 with Potent Antitumor Activity In Vitro and In Vivo
- Cytotoxic, antioxidative, genotoxic and antigenotoxic effects of Horchata, beverage of South Ecuador
- Identification of anti-cancer agents using integrated computational tools.
- β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders.
- Pre-clinical evaluation of novel inorganic compounds as potential anticancer therapies
- 2-Methylpyridine-1-ium-1-sulfonate as an Inducer of Apoptosis and Cell Cycle Arrest: A comparative in vitro and Computational Study
- Age-dependent effects of floxuridine (FUdR) on senescent pathology and mortality in the nematode Caenorhabditis elegans.
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