Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.
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Summary
The data indicate that ME-1 deficiency does not adversely affect GSH-dependent detoxification, and that mod1(-/-) mice are not more sensitive to acetaminophen hepato-toxicity.
- Type
- article
- Published
- 2008-07-01
- Cited by
- 9
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988405242
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28172375
Keywords
Glutathione, Malic enzyme, Detoxification (alternative medicine), Oxidative decarboxylation, Biochemistry
References
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- N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.
- Purification, characterization and kinetic mechanism of glucose-6-phosphate dehydrogenase from mouse liver.
- Metabolic effects induced by long-term feeding of medium-chain triglycerides in the rat.
- Characterization of cytosolic malic enzyme in human tumor cells
- Relationship of the oxidative pentose shunt pathway to lipid synthesis in Drosophila melanogaster
- Malic enzyme levels are increased by the activation of NADPH‐consuming pathways: detoxification processes
- Protection against acetaminophen‐induced liver injury and lethality by interleukin 10: Role of inducible nitric oxide synthase
- MALIC ENZYME AND LIPOGENESIS.
- High malic enzyme activity in tumor cells and its cross-reaction with antipigeon liver malic enzyme serum
- Inflammation, stress, and diabetes.
- Identification and biochemical analysis of mouse mutants deficient in cytoplasmic malic enzyme.
- An Analysis of the Relationships Among Obesity, Plasma Insulin, and Hepatic Lipogenic Enzymes in "Viable Yellow Obese" Mice (Avy/a)*
- Ontogeny, cell distribution, and the physiological role of NADP-malic enzyme in Drosophila melanogaster
- An integrative genomics approach to infer causal associations between gene expression and disease
- Acetaminophen-induced hepatotoxicity.
Cited by
- Molecular and Clinical Characterization of Syndromes Associated With Intellectual Disability
- Effects of glucose, insulin and triiodothyroxine on leptin and leptin receptor expression and the effects of leptin on activities of enzymes related to glucose metabolism in grass carp (Ctenopharyngodon idella) hepatocytes
- OXIDATIVE STRESS, INFLAMMATION AND CARCINOGENESIS ARE CONTROLLED THROUGH THE PENTOSE PHOSPHATE PATHWAY BY TRANSALDOLASE
- Interstitial Deletions at 6q14.1–q15 Associated with Obesity, Developmental Delay and a Distinct Clinical Phenotype
- Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes
- Validation of Candidate Causal Genes for Abdominal Obesity Which Affect Shared Metabolic Pathways and Networks
- Caloric Restriction Remodels Energy Metabolic Pathways of Gut Microbiota and Promotes Host Autophagy
- Divergent effects of glutathione depletion on isocitrate dehydrogenase 1 and the pentose phosphate pathway in hamster liver
- Changes in Glutathione Content in Liver Diseases: An Update
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