Hypoxia or in situ normoxia: The stem cell paradigm
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Summary
The basic principle of stem cell biology, “the generation‐age hypothesis,” and hypoxic metabolic properties of stem cells are considered in the context of the oxygen‐dependent evolution of life and its transposition to ontogenesis and development.
- Type
- review
- Published
- 2009-05-01
- Cited by
- 391
- References
- 108
- OpenAlex
- https://openalex.org/W1988357840
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39536321
Keywords
Stem cell, Hypoxia (environmental), Biology, Cell biology, Population
References
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- Retinal degeneration and local oxygen metabolism.
- Very Low O2 Concentration (0.1%) Favors G0 Return of Dividing CD34+ Cells
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- Divergent effects of hypoxia on dendritic cell functions.
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- Comparison of skeletal muscle PO2, PCO2, and pH with gastric tonometric P(CO2) and pH in hemorrhagic shock.
- Effects of hypoxic gas mixtures on viability, expression of adhesion molecules, migration, and synthesis of interleukins by cultured human endothelial cells
- Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells.
- Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Cited by
- Response of Adipose Tissue-Derived Stromal Cells in Tissue-Related O2 Microenvironment to Short-Term Hypoxic Stress
- Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.
- CD47-Dependent Regulation of H2S Biosynthesis and Signaling in T Cells
- Chromosomal instability in in vitro cultured mouse hematopoietic cells associated with oxidative stress.
- The role of host cell factors in the lytic reactivation of Kaposi's sarcoma-associated herpesvirus from latency
- The isolation and culture of human cord blood-derived mesenchymal stem cells under low oxygen conditions.
- Potential for osteogenic and chondrogenic differentiation of MSC.
- Characterizing Hypoxia and Its Behavioral Effects In 3-Dimensional Cell Aggregates
- Mesenchymal stem cells as trophic mediators of neural differentiation
- Oxygen-dependent Regulation of HIF-1alpha Expression and Function
- Hydrogen peroxide modulation of angiogenic factors in tumor cells
- In vitro and in vivo aspects of intrinsic radiosensitivity
- Microglia differentiation and cell therapie
- Adipose tissue secretion and inflammation - Characterization of novel adipokines and the impact of hypoxia on adipocyte function
- Developing a standardised manufacturing process for the clinical-scale production of human mesenchymal stem cells
- Investigation into the potential of Human Amniotic Fluid-Derived Stem Cells for use in Orthopaedic Tissue Engineering
- Mikroprostředí nádoru - možnosti výzkumu v podmínkách in vitro Tumor Microenvironment - Possibilities of the Research Under In Vitro Conditions
- Ex vivo expansion of cord blood haematopoietic stem/progenitor cells under physiological oxygen tensions: clear‐cut effects on cell proliferation, differentiation and metabolism
- The Role of Oxygen During In Vitro Culture and Immunoisolation of Islets of Langerhans
- Thrombopoietin to replace megakaryocyte‐derived growth factor: impact on stem and progenitor cells during ex vivo expansion of CD34+ cells mobilized in peripheral blood
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