Synonymous and Nonsynonymous Substitutions in Mammalian Genes: Intragenic Correlations
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Summary
The results obtained show that the intragenic variability in synonymous rates is correlated with that of nonsynonymous rates, and the variation in GC level (and especially of C level) of silent positions along each gene is correlation with the variations in synonymous rate.
- Type
- article
- Published
- 1998-01-01
- Cited by
- 54
- References
- 10
- OpenAlex
- https://openalex.org/W1988328886
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10012090
Keywords
Nonsynonymous substitution, Biology, Synonymous substitution, Gene, Genetics
References
- Molecular Evolutionary Genetics
- CORRELATION BETWEEN SYNONYMOUS AND NONSYNONYMOUS SUBSTITUTIONS
- Fundamentals of molecular evolution
- Fundamentals of molecular evolution
- Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.
- Mutation rates differ among regions of the mammalian genome
- Recent development of the neutral theory viewed from the Wrightian tradition of theoretical population genetics.
- Synonymous codon usage in Drosophila melanogaster: natural selection and translational accuracy.
- Atlas of protein sequence and structure
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- Isochores and the evolutionary genomics of vertebrates.
- Local effects of limited recombination in Drosophila
- Gene Expression, Amino Acid Conservation, and Hydrophobicity Are the Main Factors Shaping Codon Preferences in Mycobacterium tuberculosis and Mycobacterium leprae
- The genome organization of angiosperms.
- The effect of tandem substitutions on the correlation between synonymous and nonsynonymous rates in rodents.
- Rates of nucleotide substitution and mammalian nuclear gene evolution. Approximate and maximum-likelihood methods lead to different conclusions.
- Isochore evolution in mammals: a human-like ancestral structure.
- Molecular adaptation of alanine:glyoxylate aminotransferase targeting in primates.
- Inaccurate reconstruction of ancestral GC levels creates a "vanishing isochores" effect.
- Male-Driven Evolution Among Eoaves? A Test of the Replicative Division Hypothesis in a Heterogametic Female (ZW) System
- Intron Length and Codon Usage
- Synonymous and Nonsynonymous Substitutions in Genes from Gramineae: Intragenic Correlations
- A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate.
- Cytonuclear disequilibria in wild populations of rabbit (Oryctolagus cuniculus L.) suggest unequal allele turnover rates at the b locus (IGKC1)
- Mutation is modulated: implications for evolution.
- Compositional Properties of Homologous Coding Sequences from Plants
- Enhanced Synonymous Site Divergence in Positively Selected VertebrateAntimicrobial Peptide Genes
- Silent mutations in the gene encoding the p53 protein are preferentially located in conserved amino acid positions and splicing enhancers.
- Performance of likelihood ratio tests of evolutionary hypotheses under inadequate substitution models.
- Variation in synonymous substitution rates among mammalian genes and the correlation between synonymous and nonsynonymous divergences
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