Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats
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Summary
The efficacy of the natural anti-oxidants vitamins C, E and Β-carotene in preventing nerve conduction and nutritive blood flow deficits in streptozotocin-diabetic rats is examined and shows that naturally available scavengers have a neuroprotective action.
- Type
- article
- Published
- 1995-11-01
- Cited by
- 67
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988167160
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20025527
Keywords
Nerve conduction velocity, Internal medicine, Diabetes mellitus, Endocrinology, Vitamin E
References
- Hypoxic effect of exogenous insulin on normal and diabetic peripheral nerve.
- An introduction to free radical biochemistry.
- Nerve blood flow and oxygen delivery in normal, diabetic, and ischemic neuropathy.
- Glucose availability and sensitivity to anoxia of isolated rat peroneal nerve.
- Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications.
- Direct observation of a free radical interaction between vitamin E and vitamin C
- Vascular factors in diabetic neuropathy
- Effect of alpha-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve.
- Hydroxyl radicals mediate injury to endothelium-dependent relaxation in diabetic rat
- Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats
- Effects of evening primrose oil treatment on sciatic nerve blood flow and endoneurial oxygen tension in streptozotocin-diabetic rats
- Alterations in Free Radical Tissue-Defense Mechanisms in Streptozocin-Induced Diabetes in Rat: Effects of Insulin Treatment
- Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rats.
- The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats.
- The effects of glucose on ascorbic acid uptake in heart endothelial cells: possible pathogenesis of diabetic angiopathies.
- Muscle and nerve dysfunction in rats with experimental galactosaemia
- Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: Dose-response considerations and independence from a myo-inositol mechanism
- Impaired blood flow and arterio-venous shunting in human diabetic neuropathy: a novel technique of nerve photography and fluorescein angiography
- The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications.
- Metabolic Control May Influence the Increased Superoxide Generation in Diabetic Serum
Cited by
- Impact of selenium, iron, copper and zinc in on/off Parkinson's patients on L-dopa therapy.
- Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
- Development of atherosclerosis in the diabetic BALB/c mice. Prevention with Vitamin E administration.
- Nerve and ganglion blood flow in diabetes: an appraisal.
- Effects of the ascorbic acid supplementation on NADH-diaphorase myenteric neurons in the duodenum of diabetic rats.
- Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study.
- Altered arachidonic acid biosynthesis and antioxidant protection mechanisms in Schwann cells grown in elevated glucose
- Vitamin E (α‐tocopherol) supplementation enhances nitric oxide production in penile tissue of diabetic rats
- Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy.
- A Novel Animal Model of Impaired Glucose Tolerance Induced by the Interaction of Vitamin E Deficiency and 60Co Radiation
- Vitamin E (α-tocopherol) supplementation in diabetic rats: effects on the proximal colon
- Reactive oxygen species, apoptosis and alte1red NGF-induced signaling in PC12 pheochromocytoma cells cultured in elevated glucose: AnIn Vitro cellular model for diabetic neuropathy
- Neurovascular disease, antioxidants and glycation in diabetes
- Effects of Trientine, a Metal Chelator, on Defective Endothelium-dependent Relaxation in the Mesenteric Vasculature of Diabetic Rats
- Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy.
- Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat
- REMEDIAL EFFECTS OF VITAMIN E AND L-ARGININE ON PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
- Glutamate Carboxypeptidase Inhibition Reduces the Severity of Chemotherapy-Induced Peripheral Neurotoxicity in Rat
- Effect of ascorbic acid treatment on endothelium‐dependent and neurogenic relaxation of corpus cavernosum from middle‐aged non‐insulin dependent diabetic rats
- EFFECTS OF TROLOX ON NERVE DYSFUNCTION, THERMAL HYPERALGESIA AND OXIDATIVE STRESS IN EXPERIMENTAL DIABETIC NEUROPATHY
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