Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR
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Summary
Using a new bacterial two-hybrid system that selects for loss of protein interactions, 22 amino acids in the N-terminal PAS domain of Arnt are identified that are involved in heterodimerization with aryl hydrocarbon receptor (AhR).
- Type
- article
- Published
- 2011-01-17
- Cited by
- 45
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1988163785
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5788431
Keywords
Aryl hydrocarbon receptor nuclear translocator, PAS domain, Aryl hydrocarbon receptor, Biology, Transcription factor
References
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- An atlas of combinatorial transcriptional regulation in mouse and man
- A generic protein purification method for protein complex characterization and proteome exploration
- Protein‐protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor‐Arnt transcription factor complex.
- Heterodimers of bHLH-PAS protein fragments derived from AhR, AhRR, and Arnt prepared by co-expression in Escherichia coli: characterization of their DNA binding activity and preparation of a DNA complex.
- Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.
- Characterization by in vitro complementation of a peptide corresponding to an operator-proximal segment of the beta-galactosidase structural gene of Escherichia coli.
- Role of the Per/Arnt/Sim Domains in Ligand-dependent Transformation of the Aryl Hydrocarbon Receptor*
- Functions of the Per/ARNT/Sim Domains of the Hypoxia-inducible Factor*
- The structural basis of cooperative regulation at an alternate genetic switch.
- Constitutive Function of the Basic Helix-Loop-Helix/PAS Factor Arnt.
- Definition of a Dioxin Receptor Mutant That Is a Constitutive Activator of Transcription
- Separation of Retinoid X Receptor Homo- and Heterodimerization Functions
- Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD.
- Phosphorylation inhibits DNA-binding of alternatively spliced aryl hydrocarbon receptor nuclear translocator.
- Structure of a Conserved Dimerization Domain within the F-box Protein Fbxo7 and the PI31 Proteasome Inhibitor*
- Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus*
- Different transcriptional properties of mSim‐1 and mSim‐2
- Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter
- A positive genetic selection for disrupting protein-protein interactions: identification of CREB mutations that prevent association with the coactivator CBP.
Cited by
- Méthylations de l'histone H3 et contrôle épigénétique des propriétés des cellules souches de gliomes
- Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function
- FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β
- Differential suppression of the aryl hydrocarbon receptor nuclear translocator-dependent function by an aryl hydrocarbon receptor PAS-A-derived inhibitory molecule
- Exploring the Functional Residues in a Flavin-Binding Fluorescent Protein Using Deep Mutational Scanning
- Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain
- Promoter Activation by CII, a Potent Transcriptional Activator from Bacteriophage 186*
- bHLH–PAS proteins in cancer
- Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.
- A network model for angiogenesis in ovarian cancer
- Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System
- Aryl hydrocarbon receptor (AHR) in the cnidarian Nematostella vectensis: comparative expression, protein interactions, and ligand binding
- Reciprocal regulation of the basic helix–loop–helix/Per–Arnt–Sim partner proteins, Arnt and Arnt2, during neuronal differentiation
- Embryoprotein TWIST distribution in breast cancer cells MDA-MB-231 treated with 5-Fluorouracil and malnutrition
- Xenobiotics and Loss of Cell Adhesion Drive Distinct Transcriptional Outcomes by Aryl Hydrocarbon Receptor Signaling
- Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor PAS-A Domain
- Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides
- bHLH-PAS proteins: functional specification through modular domain architecture
- Mecanismos de acción del receptor de hidrocarburos de arilos en el metabolismo del benzo[a]pireno y el desarrollo de tumores
- Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation
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