Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis

Keywords

Adrenodoxin, Ferredoxin, Biochemistry, Iron–sulfur cluster, Heme

References

• The Heme Synthesis Defect of Mutants Impaired in Mitochondrial Iron-Sulfur Protein Biogenesis Is Caused by Reversible Inhibition of Ferrochelatase*Alberto Echaluce — 2004
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• Chapter 12 Controlled expression of iron-sulfur cluster assembly components for respiratory chain complexes in mammalian cells.Oliver Stehling, Alex D. Sheftel, Roland Lill — 2009
• Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cellsPaul M. Hwang, Fred Bunz, Jian Yu — 2001
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• Overview of iron--sulfur proteins.W H Orme-Johnson, N R Orme-Johnson — 1978
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• Iron-sulfur proteins in health and disease.Alex D. Sheftel, Oliver Stehling, Roland Lill — 2010
• Adrenodoxin: Structure, stability, and electron transfer propertiesAsya V. Grinberg, Frank Hannemann, Burkhard Schiffler — 2000
• Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy.Hana Antonická, André Mattman, Christopher G. Carlson — 2003
• A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins.Heike Lange, Anita Kaut, Gyula Kispál — 2000
• New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108).Alexander J. Muller, Jürgen Müller, Yves A. Muller — 1998
• Characterization of Iron-Sulfur Protein Assembly in Isolated MitochondriaUlrich Mühlenhoff, Nadine Richhardt, Jana Gerber — 2002
• Pattern of Expression and Substrate Specificity of Chloroplast Ferredoxins from Chlamydomonas reinhardtii*Aimee M. Terauchi, Shu‐Fen Lu, Mirko Zaffagnini — 2009
• Molecular evolution before the origin of species.Brian K. Davis — 2002
• Iron transport in K562 cells: a kinetic study using native gel electrophoresis and 59Fe autoradiography.Daniel Vyoral, Jir̆ı́ Petrák — 1998

Cited by

• Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia.Miguel Giménez Montesinos — 2014
• Etude de la voie du coenzyme Q¦ chez la levure Saccharomyces cerevisiaeMohammad Ozeir — 2012
• The mitochondrial redox regulation of steroidogenesisAliesha Griffin — 2015
• Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe–S Assembly ComplexNicholas G. Fox, Deepika Sharma Das, Mrinmoy Chakrabarti — 2015
• New Methodology for Measuring Semantic Functional Similarity Based on Bidirectional IntegrationXuewen Chen, Bo Luo, Jong Cheol Jeong — 2013
• Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxinHolger Webert, Sven‐Andreas Freibert, Angelo Gallo — 2014
• Optimierung der Identifizierungsstrategie von Proteinsignaturen aus Gewebe und Plasma: Proteomanalyse von Conn-Tumoren und RektumkarzinomMüzeyyen Sevim — 2015
• Early steps in steroidogenesis: intracellular cholesterol traffickingWalter L. Miller, Himangshu S. Bose — 2011
• ISC-like [2Fe–2S] ferredoxin (FdxB) dimer from Pseudomonas putida JCM 20004: structural and electron–nuclear double resonance characterizationToshio Iwasaki, Reinhard Kappl, Gerhard Bracic — 2011
• Adrenodoxin: the archetype of vertebrate-type [2Fe-2S] cluster ferredoxins.Kerstin Maria Ewen, Michael Kleser, Rita Bernhardt — 2011
• Mammalian iron metabolism and its control by iron regulatory proteinsCole Anderson, Macy Shen, Richard S. Eisenstein — 2012
• Human CIA2A (FAM96A) and CIA2B (FAM96B) integrate maturation of different subsets of cytosolic-nuclear iron-sulfur proteins and iron homeostasisOliver Stehling, Judita Mascarenhas, Ajay A. Vashisht — 2013
• Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.Darius J.R. Lane, Angelica M. Merlot, Michael Huang — 2015
• Human Ferredoxin-2 Displays a Unique Conformational ChangeWenbin Qi, Jingwei Li, J. A. Cowan — 2012
• Functional characterization of Fdx1: evidence for an evolutionary relationship between P450-type and ISC-type ferredoxins.Kerstin Maria Ewen, Frank Hannemann, Stefania Iametti — 2011
• Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency.Mohammad Ozeir, Ulrich Mühlenhoff, Holger Webert — 2011
• Transcriptional regulation of human ferredoxin reductase through an intronic enhancer in steroidogenic cells.Yoshitaka Imamichi, Tetsuya Mizutani, Yunfeng Ju — 2014
• The Long History of Iron in the Universe and in Health and DiseaseAlex D. Sheftel, Anne B. Mason, Prem Ponka — 2011
• [2Fe-2S]-Ferredoxin Binds Directly to Cysteine Desulfurase and Supplies an Electron for Iron–Sulfur Cluster Assembly but Is Displaced by the Scaffold Protein or Bacterial FrataxinJin Hae Kim, Ronnie O. Frederick, Nichole M. Reinen — 2013
• Adrenodoxin—A versatile ferredoxinKerstin Maria Ewen, Michael Ringle, Rita Bernhardt — 2012

Related papers

• Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin.Merche Faro, Burkhard Schiffler, Achim Heinz — 2003
• Immunogold staining of cytochrome P-450 cholesterol side chain cleavage enzyme (P450scc) in steroidogenic tissueJoseph Orly, Rina Timberg — 1985
• Adrenodoxin: Structure, stability, and electron transfer propertiesAsya V. Grinberg, Frank Hannemann, Burkhard Schiffler — 2000
• Molecular recognition and electron transfer in mitochondrial steroid hydroxylase systems.Larry E. Vickery — 1997
• Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase.Robert C. Tuckey, Madeleine J. Headlam — 2002
• Predictive reconstruction of the mitochondrial iron–sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin–ferredoxin reductase (Yah1–Arh1)Rui Alves, Enrique Herrero, Albert Sorribas — 2004
• Structural investigations of the environment of the iron-sulfur cluster of the 2-iron ferredoxins.J. Drum, Kerry T. Yasunobu, Roger E. Cramer — 1976
• Deletions in the loop surrounding the iron-sulfur cluster of adrenodoxin severely affect the interactions with its native redox partners adrenodoxin reductase and cytochrome P450(scc) (CYP11A1).Andy Zöllner, Frank Hannemann, Michael Lisurek — 2002
• EPR and redox characterization of ferredoxins I and II from Desulfovibrio vulgaris Miyazaki.Marcel Asso, Omar Mbarki, Bruno Guigliarelli — 1995