Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive Effect of Chlorothiazide
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Summary
The present investigation indicates that the lowering of blood pressure is accompanied by reductions in plasma and extracellular fluid volumes and in body weight, and re-expansion of plasma volume with salt-free dextran reverses the antihypertensive effect.
- Type
- article
- Published
- 1959-12-01
- Cited by
- 187
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W1987480023
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1454390
Keywords
Chlorothiazide, Extracellular fluid, Extracellular, Plasma volume, Medicine
References
- A SIMPLE AND ACCURATE METHOD FOR THE DETERMINATION OF CHLORIDE IN BIOLOGICAL FLUIDS
- CHLOROTHIAZIDE IN HYPERTENSION: STUDIES ON ITS MODE OF ACTION
- Changes in the volume of the plasma, interstitial and intracellular fluid spaces during hydration and dehydration in normal and edematous subjects.
- A Mechanism of Chlorothiazide‐Enhanced Effectiveness of Antihypertensive Ganglioplegic Drugs
- An evaluation of radiosulfate for the determination of the volume of extracellular fluid in man and dogs.
- CHLOROTHIAZIDE IN HYPERTENSIVE AND NORMOTENSIVE PATIENTS
- Effect of hypertension on arterial wall electrolytes during desoxycorticosterone administration.
Cited by
- The distribution of body sodium and potassium following diuretic therapy
- Diuretics II: Clinical Considerations
- Physiology of epithelial Ca2+ and Mg2+ transport.
- Hemodynamic changes in long-term diuretic therapy of essential hypertension. A comparative study of chlorthalidone, polythiazide and hydrochlorothiazide.
- カリウム代謝動態の計量解析―利尿反応の直線表示による尿K/Na比の補正法の吟味―
- Lack of effect of bumetanide on body potassium content in hypertension.
- Diuretyki w leczeniu hipotensyjnym — nowe doniesienia, stare wątpliwości. Czas na rozsądny wybór?
- Effect of chlorothiazide upon aldosterone excretion and sodium and potassium balance in essential hypertension.
- Hemodynamic effects of antihypertensive agents.
- Whole‐Body Circulatory Autoregulation and Hypertension
- Interpretation of measured red cell mass and plasma volume in males with elevated venous PCV values.
- The pharmacology and clinical use of diuretics in the treatment of hypertension
- Double-blind trial of antihypertensive effect of chlorothiazide in severe renal failure.
- A review of the benzothiadiazine derivatives in relation to cardiovascular disease.
- Central hemodynamic effects of diuretic therapy in chronic heart failure
- Thiazide and Thiazide-like Diuretics: An Opportunity to Reduce Blood Pressure in Patients with Advanced Kidney Disease
- The mechanisms of action of antihypertensive drugs.
- Persistence of normal BP after withdrawal of drug treatment in mild hypertension.
- Long-term clonidine effects on autonomic function in essential hypertensive man
- Hypertension: from theory to therapy
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