Clinically relevant molecular subtypes in leiomyosarcoma
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Summary
The leiomyosarcoma subtypes showed significant differences in expression levels for genes for which novel targeted therapies are being developed, suggesting that leiOSarcomA subtypes may respond differentially to these targeted therapies.
- Type
- article
- Published
- 2015-04-20
- Cited by
- 135
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1987085807
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2195357
Keywords
Leiomyosarcoma, Immunohistochemistry, Cancer, Tissue microarray, Biology
References
- Uncovering rate variation of lateral gene transfer during bacterial genome evolution
- IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A
- The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
- Stromal responses among common carcinomas correlated with clinicopathologic features
- Silhouettes: a graphical aid to the interpretation and validation of cluster analysis
- Gene Expression Profiling in Leiomyosarcomas and Undifferentiated Pleomorphic Sarcomas: SRC as a New Diagnostic Marker
- 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma
- Expression of subtype-specific Group 1 leiomyosarcoma markers in a wide variety of sarcomas by gene expression analysis and immunohistochemistry
- Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
- Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin?
- Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy
- Software tools for high-throughput analysis and archiving of immunohistochemistry staining data obtained with tissue microarrays.
- Progressive Loss Of Myogenic Differentiation In Leiomyosarcoma Has Prognostic Value
- The Macrophage Colony Stimulating Factor-1 Response Signature in Breast Carcinoma
- Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma
- Soft tissue leiomyosarcoma. A population‐based epidemiologic and prognostic study of 48 patients, including cellular dna content
- Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling
- Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology
- Smooth muscle differentiation identifies two classes of poorly differentiated pleomorphic sarcomas with distinct outcome
- Subclass Mapping: Identifying Common Subtypes in Independent Disease Data Sets
Cited by
- Notch pathway inhibition with LY3039478 in soft tissue sarcoma and gastrointestinal stromal tumours.
- OSlms: A Web Server to Evaluate the Prognostic Value of Genes in Leiomyosarcoma
- Molecular subtyping of leiomyosarcoma with 3′ end RNA sequencing
- Advances in the Molecular Analysis of Soft Tissue Tumors and Clinical Implications
- Massive parallel sequencing in sarcoma pathobiology: state of the art and perspectives
- Clinical and prognostic significance of Arl4c expression in colorectal cancer
- Unusual Cardiac Metastasis of Uterine Leiomyosarcoma: Case Report and Literature Review
- Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers.
- Sarcoma: Olaratumab — really a breakthrough for soft-tissue sarcomas?
- Gene expression profiling identifies distinct molecular subgroups of leiomyosarcoma with clinical relevance
- Arf proteins in cancer cell migration
- Molecular Targets and Emerging Therapeutic Options for Uterine Leiomyosarcoma
- Survival of patients with metastatic leiomyosarcoma: the MD Anderson Clinical Center for targeted therapy experience
- Identification of distinct molecular subtypes of uterine carcinosarcoma
- Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative
- Molecular characteristics of uterine sarcomas
- Phase III Soft Tissue Sarcoma Trials: Success or Failure?
- Defining Novel Molecular Events in Leiomyosarcoma
- Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas.
- Validation of a Mitotic Index Cutoff as a Prognostic Marker in Undifferentiated Uterine Sarcomas
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