Novel regulators of bone formation: molecular clones and activities.
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Summary
Human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained, and each appears to be independently capable of inducing the formation of cartilage in vivo.
- Type
- article
- Published
- 1988-12-16
- Cited by
- 4,020
- References
- 36
- OpenAlex
- https://openalex.org/W1986469118
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12330100
Keywords
Bone morphogenetic protein, Cartilage, Bone morphogenetic protein 2, Cell biology, Recombinant DNA
References
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- Importance of FSH-releasing protein and inhibin in erythrodifferentiation
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- ALK1 et BMP9 dans le remodelage vasculaire de la génétique humaine aux modèles murins
- Accelerated endochondral osteoinduction in the absence of bone matrix particles in a rat model system.
- Inhibition of prolactin gene transcription by transforming growth factor-beta in GH3 cells.
- Characterization of bone‐derived chondrogenesis‐stimulating activity on embryonic limb mesenchymal cells in vitro
- Using purified protein to clone its gene.
- Initiation and promotion of bone differentiation by bone morphogenetic proteins
- Expression of the alpha subunit of PABA peptide hydrolase (EC 3.4.24.18) in MDCK cells
- Bone morphogenetic protein expression in human atherosclerotic lesions.
- Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system.
- Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7).
- Histologic examination of meniscal repair in rabbits.
- Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica
- Inductive properties of recombinant human BMP-2 produced in a bacterial expression system.
- Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases
- Sea urchin TgBMP2/4 gene encoding a bone morphogenetic protein closely related to vertebrate BMP2 and BMP4 with maximal expression at the later stages of embryonic development.
- Role of polypeptides in the treatment and diagnosis of osteoporosis.
- Bone morphogenetic proteins in human bone regeneration.
- In vivo bone-forming capacity of human bone marrow-derived stromal cells is stimulated by recombinant human bone morphogenetic protein-2
- Bone Morphogenetic Protein Gene Therapy
- Use of Recombinant Human Bone Morphogenetic Protein-2 to Achieve Posterolateral Lumbar Spine Fusion in Humans: A Prospective, Randomized Clinical Pilot Trial 2002 Volvo Award in Clinical Studies
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