The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death induction.
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Summary
Site-directed mutagenesis of the RPS4 TIR domain identified many loss-of-function mutations but also revealed several gain-of function substitutions, consistent with previous observations that the TIRdomain itself is insufficient to induce cell death upon transient expression.
- Type
- article
- Published
- 2009-01-08
- Cited by
- 208
- References
- 57
- OpenAlex
- https://openalex.org/W1985835804
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20299967
Keywords
Programmed cell death, Biology, Nicotiana benthamiana, Cell biology, Signal transduction
References
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- The Interleukin 1 (IL-1) Receptor Accessory Protein Toll/IL-1 Receptor Domain
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- Identification and Characterization of Crr1a, a Gene for Resistance to Clubroot Disease (Plasmodiophora brassicae Woronin) in Brassica rapa L.
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