The P-loop--a common motif in ATP- and GTP-binding proteins.
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Summary
Current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function.
- Type
- review
- Published
- 1990-11-01
- Cited by
- 2,018
- References
- 25
- OpenAlex
- https://openalex.org/W1985744441
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44601237
Keywords
GTP', Binding site, Biochemistry, Sequence motif, Threonine
References
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- The predicted secondary structures of the nucleotide-binding sites of six cation-transporting ATPases lead to a probable tertiary fold.
- The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
- Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
- Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria.
- G protein multiplicity in eukaryotic signal transduction systems.
- Three-dimensional structure of the complex of guanylate kinase from yeast with its substrate GMP.
- Structure of ras proteins.
- Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli.
- Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli.
Cited by
- Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP
- Cytoskeletal filament systems : assembly, regulation, and interplay in mammalian cells
- Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus
- Cloning and sequencing of the tuf genes of Streptomyces coelicolor A3(2).
- Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?
- Extracting protein alignment models from the sequence database.
- The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment
- Molecular Cloning and Expression of Mouse and Human cDNAs Encoding Heparan Sulfate d-Glucosaminyl 3-O-Sulfotransferase*
- Genetic and biochemical analyses of Actinobacillus pleuropneumoniae urease
- The Escherichia coli dnaA gene: four functional domains.
- The Anopheles albimanus white gene: molecular characterization of the gene and a spontaneous white gene mutation
- The HPr Kinase from Bacillus subtilis Is a Homo-oligomeric Enzyme Which Exhibits Strong Positive Cooperativity for Nucleotide and Fructose 1,6-Bisphosphate Binding*
- Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate.
- Characterization of two PR genes from Fragaria chiloensis in response to Botrytis cinerea infection: A comparison with Fragaria x ananassa
- Identification of an extracellular motif involved in the binding of guanine nucleotides by a glutamate receptor.
- Molecular cloning and functional characterization of a novel delayed rectifier potassium channel from channel catfish (Ictalurus punctatus): expression in taste buds
- The metDd-Methionine Transporter Locus of Escherichia coli Is an ABC Transporter Gene Cluster
- GTPase catalysis by Ras and other G-proteins: insights from Substrate Directed SuperImposition.
- Molecular Design and Functional Organization of the RecA Protein
- Identification and mapping of resistance gene analogs and a white rust resistance locus in Brassica rapa ssp. oleifera
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