Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.
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Summary
A mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and regulates their memory cell potential is elucidated.
- Type
- article
- Published
- 2007-08-24
- Cited by
- 1,946
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985294654
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25170971
Keywords
Effector, Biology, Transcription factor, Cell biology, Inflammation
References
- Cytokine control of memory T-cell development and survival
- Cytokines and Transcription Factors That Regulate T Helper Cell Differentiation: New Players and New Insights
- Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
- Induction and regulation of IL-15 expression in murine macrophages.
- Generation of CD8 T Cell Memory Is Regulated by IL-121
- Cutting Edge: Latecomer CD8 T Cells Are Imprinted with a Unique Differentiation Program1
- Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination.
- IL-15 Regulates CD8+ T Cell Contraction during Primary Infection1
- Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
- The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained.
- Temporal Dissection of T-bet Functions1
- Expression of Killer Cell Lectin-Like Receptor G1 on Antigen-Specific Human CD8+ T Lymphocytes during Active, Latent, and Resolved Infection and its Relation with CD57
- A novel transcription factor, T-bet, directs Th1 lineage commitment.
- Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor
- Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
- Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
- Direct effects of T‐bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation
- Lineage relationship and protective immunity of memory CD8 T cell subsets
- Expression of IL-7 receptor α is necessary but not sufficient for the formation of memory CD8 T cells during viral infection
Cited by
- Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation
- Regulation of memory CD8 T cell differentiation
- Epitope Specificity and Relative Clonal Abundance Do Not Affect CD8 Differentiation Patterns during Lymphocytic Choriomeningitis Virus Infection
- Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination.
- Like parent, like child: inheritance of effector CD8+ T cell traits.
- FoxP3+ regulatory CD4 T cells control the generation of functional CD8 memory
- TGF-β Sensitivity Restrains CD8+ T Cell Homeostatic Proliferation by Enforcing Sensitivity to IL-7 and IL-15
- T cell Vaccinology: Exploring the known unknowns
- Disparate roles for STAT5 in primary and secondary CTL responses
- High viral burden restricts short-lived effector cell (SLEC) number at late times postinfection through increased nTreg expansion
- T cell responses: naive to memory and everything in between.
- Memory CD4 T cells in Influenza
- The multifaceted role of CD4+ T cells in the regulation of CD8+ T cell memory maturation
- Eomesodermin promotes interferon‐γ expression and binds to multiple conserved noncoding sequences across the Ifng locus in mouse thymoma cell lines
- Nano-Pulse Stimulation Ablates Orthotopic Rat Hepatocellular Carcinoma and Induces Innate and Adaptive Memory Immune Mechanisms that Prevent Recurrence
- Model-Based Assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-Cell Immune Responses
- Mouse T cells express a neurotransmitter-receptor signature that is quantitatively modulated in a subset and activation dependent manner
- Mechanisms of Lung Surveillance by Pathogen-Specific Cytotoxic T Lymphocytes
- Targeting Wnt Signaling in the Tumor Immune Microenvironment to Enhancing EpCAM CAR T-Cell therapy
- Roles for the aryl hydrocarbon receptor in the immune response to Toxoplasma gondii
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