MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels
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Summary
The envelope protein of MERS coronavirus (MERS-CoV E protein) has been purified and the full length construct obtained is amenable to structural determination by NMR in detergents.
- Type
- article
- Published
- 2015-02-27
- Cited by
- 98
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985220941
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40902213
Keywords
Biology, Coronavirus, Envelope (radar), Ion channel, Transmembrane domain
References
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- The Missing Link in Coronavirus Assembly
- Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein
- Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel
- Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties.
- A structural analysis of M protein in coronavirus assembly and morphology
- Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein
- Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication
- The Transmembrane Oligomers of Coronavirus Protein E
- Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study
- Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells
- SUBCELLULAR LOCATION AND TOPOLOGY OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS ENVELOPE PROTEIN
- Ion Channels Formed by SARS Coronavirus Envelope Protein: Lipid Regulation of Conductance and Selectivity
- On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation.
- Noise in Fourier self-deconvolution.
- Is MERS another SARS?
- A cost-effective method for simultaneous homo-oligomeric size determination and monodispersity conditions for membrane proteins.
- Immunization with an Attenuated Severe Acute Respiratory Syndrome Coronavirus Deleted in E Protein Protects Against Lethal Respiratory Disease
- Model of a Putative Pore: The Pentameric α-Helical Bundle of SARS Coronavirus E Protein in Lipid Bilayers
- Human Betacoronavirus 2c EMC/2012–related Viruses in Bats, Ghana and Europe
Cited by
- Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control
- Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome
- Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis
- A Coronavirus E Protein Is Present in Two Distinct Pools with Different Effects on Assembly and the Secretory Pathway
- The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection
- Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?
- Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus
- Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms
- Analysis of the Genome Sequence and Prediction of B-Cell Epitopes of the Envelope Protein of Middle East Respiratory Syndrome-Coronavirus
- Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): A review
- The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology
- Structural model of the SARS coronavirus E channel in LMPG micelles
- Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis
- The Infectious Bronchitis Virus Coronavirus Envelope Protein Alters Golgi pH to Protect Spike Protein and Promote Release of Infectious Virus
- Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host
- Middle East respiratory syndrome: pathogenesis and therapeutic developments
- Coronavirus envelope protein: current knowledge
- Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins
- Viroporins: A new target for fighting viral infections
- Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication
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