Kinetic Analysis of Central [11C]Raclopride Binding to D2-Dopamine Receptors Studied by PET—A Comparison to the Equilibrium Analysis
Explore this paper's citation graph
Summary
Examination of [11C]raclopride uptake in brain regions devoid of specific D2-dopamine receptor binding indicated a fourth compartment in which uptake was reversible, nonstereoselective, and nonsaturable in the dose range studied.
- Type
- article
- Published
- 1989-10-01
- Cited by
- 466
- References
- 49
- OpenAlex
- https://openalex.org/W1985050254
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42942058
Keywords
Raclopride, Chemistry, Binding potential, Radioligand, Dissociation constant
References
- Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations.
- Discriminating interactions between chiral molecules.
- Does mental activity change the oxidative metabolism of the brain?
- Positron emission tomography (PET) in the study of dopamine receptors in the primate brain: evaluation of a kinetic model using 11C‐N‐methyl‐spiperone
- Widespread distribution of brain dopamine receptors evidenced with [125I]iodosulpride, a highly selective ligand.
- Imaging dopamine receptors in the human brain by positron tomography.
- Dopamine receptor binding in vivo: the feasibility of autoradiographic studies.
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
- The Pharmacokinetics and Pharmacodynamics of d- and dl-Verapamil in Rabbits
- Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography.
- Transport of protein-bound hormones into tissues in vivo.
- Imaging of neurotransmitter receptors in the living human brain.
- The rate of triiodothyronine dissociation from binding sites in human plasma.
- Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination.
- Automated blood sampling systems for positron emission tomography
- Stereoselective clearance and distribution of intravenous propranolol
- Cerebral hemodynamics in the rat assessed by a non-diffusible indicator-dilution technique.
- Neuroreceptor Assay with Positron Emission Tomography: Equilibrium versus Dynamic Approaches
- Kinetic Modeling of Receptor‐Ligand Binding Applied to Positron Emission Tomographic Studies with Neuroleptic Tracers
- Dopamine Receptor Occupancy and Plasma Haloperidol Levels-Reply
Cited by
- Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2′-Fl8)fluoroethylspiperone and positron emission tomography
- Effect of age on D2 dopamine receptors in normal human brain measured by positron emission tomography and 11C-raclopride.
- Central 5-HT2A and D2 dopamine receptor occupancy after sublingual administration of ORG 5222 in healthy men
- PET-examination and metabolite evaluation in monkey of [(11)C]NAD-299, a radioligand for visualisation of the 5-HT(1A) receptor.
- Molecular Imaging in the Clinical Neurosciences
- The use of ¹⁸F-BCPP-EF as a PET probe for complex I activity in the brain.
- Occupancy of 5-HT1A receptors by clozapine in the primate brain: a PET study
- High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study.
- Structural and functional brain imaging in schizophrenia.
- The simplified reference tissue model for SPECT/PET brain receptor studies
- Pharmacokinetics of Raclopride Formulations
- Genetic Factors in the Regulation of Striatal and Extrastriatal Dopamine D2 Receptor Expression
- [123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter: a comparative analysis in nonhuman primates.
- PET-determination of benzodiazepine receptor binding in studies on alcoholism.
- Kinetic modeling in positron emission tomography.
- Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia.
- Where have we got to with neuroreceptor mapping of the human brain?
- Dose-dependent binding of AZD3783 to brain 5-HT 1B receptors in non-human primates and human subjects: a positron emission tomography study
- Estimation de la fonction d’entrée en tomographie par émission de positons dynamique : application au fluorodesoxyglucose
- Centrally acting dopamine D2 receptor ligands: agonists.
Related papers
- Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride
- Imaging dopamine receptors in the rat striatum with the MicroPET R4: kinetic analysis of [11C]raclopride binding using graphical methods.
- Parametric mapping of binding in human brain of D2 receptor ligands of different affinities.
- Dopamine D2/D3 receptor occupancy of apomorphine evaluated with the agonist radioligand [11C]MNPA and the antagonist radioligand [11C]Raclopride. A PET evaluation in the non-human primate brain
- Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies.
- Maps of receptor binding parameters in the human brain — a kinetic analysis of PET measurements
- Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice
- Sex differences in the striatal dopamine D2 receptor binding characteristics in vivo.
- Potentials and Pitfalls Using High Affinity Radioligands in PET and SPET Determinations on Regional Drug Induced D2 Receptor Occupancy - A Simulation Study Based on Experimental Data