Metformin therapy: Benefits beyond glycemic control
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Summary
Metformin reduces the macrovascular complications of diabetes by improving vascular endothelial functions and reducing pro-inß ammatory cytokines and oxidative stress, which can reduce cardiovascular events in patients with type 2 diabetes.
- Type
- article
- Published
- 2007-01-01
- Cited by
- 10
- References
- 28
- OpenAlex
- https://openalex.org/W1984948283
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41140921
Keywords
Medicine, Metformin, Glycemic, Diabetes mellitus, Intensive care medicine
References
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- Comparison of Rosiglitazone and Metformin for Treating HIV Lipodystrophy
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- [Effect of glucose control on lipid levels in patients with type 2 diabetes].
- Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits.
- Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.
- Improved clinical outcomes associated with metformin in patients with diabetes and heart failure.
- Pathogenesis and Management of Diabetic Dyslipidemia
- Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study.
- Metformin Inhibits Proinflammatory Responses and Nuclear Factor-&kgr;B in Human Vascular Wall Cells
- Metformin administration improves endothelial function in women with polycystic ovary syndrome.
- Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism.
- Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes.
- Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process.
- [Metformin, an efficacious drug in the treatment of polycystic ovary syndrome].
Cited by
- Prescribing Pattern of Oral Antihyperglycaemic Drugs, Rationality and Adherence to American Diabetes Association (ADA) Treatment Guidelines among Type 2 Diabetes Mellitus (T2DM) Postmenopausal Women.
- Metformin ameliorates methotrexate-induced hepatotoxicity
- The protective potential of metformin against acetaminophen-induced hepatotoxicity in BALB/C mice
- Metformin: From medieval age to new therapeutic targets
- The association between attitude, self-efficacy, and social support and adherence to diabetes self-care behavior
- Effectiveness of moringa oleifera on triglyceride levels in diabetic wistar rats (Rattus norvegicus) induced with streptozotocin (STZ)
- ANTIANXIETY EFFECT OF ETHYL PYRUVATE IN TYPE 2 DIABETIC RATS
- The Role of Metformin on Atherogenic Dyslipidemia in Poorly Controlled patients of Type-2 Diabetes Mellitus plus Metabolic Syndrome
- Hepatoprotective Potential of Metformin against Methotrexate Induced Hepatotoxicity
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